Downregulation of organic cation transporters OCT1 (<it>SLC22A1</it>) and OCT3 (<it>SLC22A3</it>) in human hepatocellular carcinoma and their prognostic significance

Downregulation of organic cation transporters OCT1 (<it>SLC22A1</it>) and OCT3 (<it>SLC22A3</it>) in human hepatocellular carcinoma and their prognostic significance

<p>Abstract</p> <p>Background</p> <p>Organic cation transporters (OCT) are responsible for the uptake and intracellular inactivation of a broad spectrum of endogenous substrates and detoxification of xenobiotics and chemotherapeutics. The transporters became pharmaceuti...

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Bibliographic Details
Main Authors: Heise Michael, Lautem Anja, Knapstein Johanna, Schattenberg Jörn M, Hoppe-Lotichius Maria, Foltys Daniel, Weiler Nina, Zimmermann Anca, Schad Arno, Gründemann Dirk, Otto Gerd, Galle Peter R, Schuchmann Marcus, Zimmermann Tim
Format: Article
Language:English
Published: BMC 2012-03-01
Series:BMC Cancer
Subjects:
OCT1
OCT3
SLC22A1
SLC22A3
Hepatocellular carcinoma
HCC
Online Access:http://www.biomedcentral.com/1471-2407/12/109

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