PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain

The cytoplasmic domain of PD-L1 (PD-L1-CD) is involved in regulating PD-L1 stability and degradation. Here the authors show that membrane binding of PD-L1-CD mediates the cellular levels of PD-L1, while metformin can disrupt the interaction between PD-L1-CD and the membrane to reduce PD-L1 levels.

Bibliographic Details
Main Authors:	Maorong Wen, Yunlei Cao, Bin Wu, Taoran Xiao, Ruiyu Cao, Qian Wang, Xiwei Liu, Hongjuan Xue, Yang Yu, Jialing Lin, Chenqi Xu, Jie Xu, Bo OuYang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-25416-7

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spelling	doaj-17e35fdce2dc46e3ae4946ce57c815872021-08-29T11:37:36ZengNature Publishing GroupNature Communications2041-17232021-08-0112111310.1038/s41467-021-25416-7PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domainMaorong Wen0Yunlei Cao1Bin Wu2Taoran Xiao3Ruiyu Cao4Qian Wang5Xiwei Liu6Hongjuan Xue7Yang Yu8Jialing Lin9Chenqi Xu10Jie Xu11Bo OuYang12State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesState Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesNational Facility for Protein Science in Shanghai, ZhangJiang lab, Shanghai Advanced Research Institute, Chinese Academy of SciencesState Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesState Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesState Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesState Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesNational Facility for Protein Science in Shanghai, ZhangJiang lab, Shanghai Advanced Research Institute, Chinese Academy of SciencesNational Facility for Protein Science in Shanghai, ZhangJiang lab, Shanghai Advanced Research Institute, Chinese Academy of SciencesDepartment of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences CenterState Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesInstitutes of Biomedical Sciences, Fudan UniversityState Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesThe cytoplasmic domain of PD-L1 (PD-L1-CD) is involved in regulating PD-L1 stability and degradation. Here the authors show that membrane binding of PD-L1-CD mediates the cellular levels of PD-L1, while metformin can disrupt the interaction between PD-L1-CD and the membrane to reduce PD-L1 levels.https://doi.org/10.1038/s41467-021-25416-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Maorong Wen Yunlei Cao Bin Wu Taoran Xiao Ruiyu Cao Qian Wang Xiwei Liu Hongjuan Xue Yang Yu Jialing Lin Chenqi Xu Jie Xu Bo OuYang
spellingShingle	Maorong Wen Yunlei Cao Bin Wu Taoran Xiao Ruiyu Cao Qian Wang Xiwei Liu Hongjuan Xue Yang Yu Jialing Lin Chenqi Xu Jie Xu Bo OuYang PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain Nature Communications
author_facet	Maorong Wen Yunlei Cao Bin Wu Taoran Xiao Ruiyu Cao Qian Wang Xiwei Liu Hongjuan Xue Yang Yu Jialing Lin Chenqi Xu Jie Xu Bo OuYang
author_sort	Maorong Wen
title	PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain
title_short	PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain
title_full	PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain
title_fullStr	PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain
title_full_unstemmed	PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain
title_sort	pd-l1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-08-01
description	The cytoplasmic domain of PD-L1 (PD-L1-CD) is involved in regulating PD-L1 stability and degradation. Here the authors show that membrane binding of PD-L1-CD mediates the cellular levels of PD-L1, while metformin can disrupt the interaction between PD-L1-CD and the membrane to reduce PD-L1 levels.
url	https://doi.org/10.1038/s41467-021-25416-7
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PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain

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