Amastin Knockdown in Leishmania braziliensis Affects Parasite-Macrophage Interaction and Results in Impaired Viability of Intracellular Amastigotes.

Amastin Knockdown in Leishmania braziliensis Affects Parasite-Macrophage Interaction and Results in Impaired Viability of Intracellular Amastigotes.

Leishmaniasis, a human parasitic disease with manifestations ranging from cutaneous ulcerations to fatal visceral infection, is caused by several Leishmania species. These protozoan parasites replicate as extracellular, flagellated promastigotes in the gut of a sandfly vector and as amastigotes insi...

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Main Authors: Rita Marcia Cardoso de Paiva, Viviane Grazielle-Silva, Mariana Santos Cardoso, Brenda Naemi Nakagaki, Rondon Pessoa Mendonça-Neto, Adriana Monte Cassiano Canavaci, Normanda Souza Melo, Patrícia Massara Martinelli, Ana Paula Fernandes, Wanderson Duarte daRocha, Santuza M R Teixeira
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-12-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4671664?pdf=render

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