Oxidative Imbalance in HIV-1 Infected Patients Treated with Antiretroviral Therapy
It is generally accepted that oxidative stress is involved in HIV infection. However, the role in oxidative balance of Highly Active Antiretroviral Therapy (HAART) is still debated. In our study we assessed serum oxidant and antioxidant levels in an HIV-1-infected population treated with HAART, and...
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doaj-17e790a4f4a74f1689f8942b1f2b8f732020-11-25T00:11:18ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512009-01-01200910.1155/2009/749575749575Oxidative Imbalance in HIV-1 Infected Patients Treated with Antiretroviral TherapyAntonella Mandas0Eugenio Luigi Iorio1Maria Gabriella Congiu2Cinzia Balestrieri3Antonello Mereu4Daniela Cau5Sandra Dessì6Nicoletta Curreli7Department of Internal Medical Sciences, University of Cagliari, SS 554 Km 4.5, 09042 Monserrato, ItalyInternational Observatory of Oxidative Stress, Free Radicals and Antioxidant Systems, Via Paolo Grisignano 21, 84127 Salerno, ItalyDepartment of Internal Medical Sciences, University of Cagliari, SS 554 Km 4.5, 09042 Monserrato, ItalyDepartment of Internal Medical Sciences, University of Cagliari, SS 554 Km 4.5, 09042 Monserrato, ItalyDepartment of Internal Medical Sciences, University of Cagliari, SS 554 Km 4.5, 09042 Monserrato, ItalyDepartment of Internal Medical Sciences, University of Cagliari, SS 554 Km 4.5, 09042 Monserrato, ItalyDepartment of Internal Medical Sciences, University of Cagliari, SS 554 Km 4.5, 09042 Monserrato, ItalyDepartment of Biomedical Science and Technology, Division of Biochemistry, University of Cagliari, SS 554 Km 4.5, 09042 Monserrato, ItalyIt is generally accepted that oxidative stress is involved in HIV infection. However, the role in oxidative balance of Highly Active Antiretroviral Therapy (HAART) is still debated. In our study we assessed serum oxidant and antioxidant levels in an HIV-1-infected population treated with HAART, and compared them with those of untreated HIV-1 patients and HIV-1-negative subjects. The study included 116 HIV-1-infected patients (86 HAART-treated and 30 untreated), and 46 HIV-negative controls. Serum oxidant levels were significantly higher in the HIV-1 treated group as compared to untreated and control groups. In addition, a decrease of serum total antioxidant status was observed in the HIV-1 treated group. To be noted is that patients who rigorously follow antiretroviral therapy (optimal HAART adherence) have significantly higher oxidative status than those who do not closely follow the therapy (poor HAART adherence). Analysis of variance revealed no significant further increase in oxidative status in HIV-1-infected patients taking antiretroviral and other drugs with the exception of psychiatric drugs (e.g. anxiolytics or antidepressants). Taken together, our results indicate that HAART may affect oxidative stress in HIV-1-infected patients and suggest that antiretroviral therapy plays an important role in the synergy of HIV infection and oxidative stress.http://dx.doi.org/10.1155/2009/749575 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Antonella Mandas Eugenio Luigi Iorio Maria Gabriella Congiu Cinzia Balestrieri Antonello Mereu Daniela Cau Sandra Dessì Nicoletta Curreli |
spellingShingle |
Antonella Mandas Eugenio Luigi Iorio Maria Gabriella Congiu Cinzia Balestrieri Antonello Mereu Daniela Cau Sandra Dessì Nicoletta Curreli Oxidative Imbalance in HIV-1 Infected Patients Treated with Antiretroviral Therapy Journal of Biomedicine and Biotechnology |
author_facet |
Antonella Mandas Eugenio Luigi Iorio Maria Gabriella Congiu Cinzia Balestrieri Antonello Mereu Daniela Cau Sandra Dessì Nicoletta Curreli |
author_sort |
Antonella Mandas |
title |
Oxidative Imbalance in HIV-1 Infected Patients Treated with Antiretroviral Therapy |
title_short |
Oxidative Imbalance in HIV-1 Infected Patients Treated with Antiretroviral Therapy |
title_full |
Oxidative Imbalance in HIV-1 Infected Patients Treated with Antiretroviral Therapy |
title_fullStr |
Oxidative Imbalance in HIV-1 Infected Patients Treated with Antiretroviral Therapy |
title_full_unstemmed |
Oxidative Imbalance in HIV-1 Infected Patients Treated with Antiretroviral Therapy |
title_sort |
oxidative imbalance in hiv-1 infected patients treated with antiretroviral therapy |
publisher |
Hindawi Limited |
series |
Journal of Biomedicine and Biotechnology |
issn |
1110-7243 1110-7251 |
publishDate |
2009-01-01 |
description |
It is generally accepted that oxidative stress is involved in HIV infection. However, the role in oxidative balance of Highly Active Antiretroviral Therapy (HAART) is still debated. In our study we assessed serum oxidant and antioxidant levels in an HIV-1-infected population treated with HAART, and compared them with those of untreated HIV-1 patients and HIV-1-negative subjects. The study included 116 HIV-1-infected patients (86 HAART-treated and 30 untreated), and 46 HIV-negative controls. Serum oxidant levels were significantly higher in the HIV-1 treated group as compared to untreated and control groups. In addition, a decrease of serum total antioxidant status was observed in the HIV-1 treated group. To be noted is that patients who rigorously follow antiretroviral therapy (optimal HAART adherence) have significantly higher oxidative status than those who do not closely follow the therapy (poor HAART adherence). Analysis of variance revealed no significant further increase in oxidative status in HIV-1-infected patients taking antiretroviral and other drugs with the exception of psychiatric drugs (e.g. anxiolytics or antidepressants). Taken together, our results indicate that HAART may affect oxidative stress in HIV-1-infected patients and suggest that antiretroviral therapy plays an important role in the synergy of HIV infection and oxidative stress. |
url |
http://dx.doi.org/10.1155/2009/749575 |
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