Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep

• Main Authors: Zengkui Lu, Yaojing Yue, Chao Yuan, Jianbin Liu, Zhiqiang Chen, Chune Niu, Xiaoping Sun, Shaohua Zhu, Hongchang Zhao, Tingting Guo, Bohui Yang
• Format: Article
• Language: English
• Published: MDPI AG 2020-01-01
• Series: Animals
• Subjects: body weight; genome-wide association study; fine-wool sheep; genomic analysis; functional analysis
• Online Access: https://www.mdpi.com/2076-2615/10/1/170

Body weight is an important economic trait for sheep and it is vital for their successful production and breeding. Therefore, identifying the genomic regions and biological pathways that contribute to understanding variability in body weight traits is significant for selection purposes. In this study, the genome-wide associations of birth, weaning, yearling, and adult weights of 460 fine-wool sheep were determined using resequencing technology. The results showed that 113 single nucleotide polymorphisms (SNPs) reached the genome-wide significance levels for the four body weight traits and 30 genes were annotated effectively, including <i>AADACL3</i>, <i>VGF</i>, <i>NPC1</i>, and <i>SERPINA12</i>. The genes annotated by these SNPs significantly enriched 78 gene ontology terms and 25 signaling pathways, and were found to mainly participate in skeletal muscle development and lipid metabolism. These genes can be used as candidate genes for body weight in sheep, and provide useful information for the production and genomic selection of Chinese fine-wool sheep.