The Potential of Circulating Tumor Cells in Personalized Management of Breast Cancer: A Systematic Review
Circulating tumor cells (CTCs) recognition and characterization in the peripheral blood of patients with breast cancer have proven practical and predictive value in different studies. However, the clinical significance of CTCs enumeration and molecular characterization in thepersonalization of brea...
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Tehran University of Medical Sciences
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doaj-17f5151e141b4dedb9b75dc4e2f5bb7f2020-11-25T03:35:01ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942017-03-015535134The Potential of Circulating Tumor Cells in Personalized Management of Breast Cancer: A Systematic ReviewFatemeh Khatami0Hamid Reza Aghayan1Maryam Sanaei2Ramin Heshmat3Seyed Mohammad Tavangar4Bagher Larijani5Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.Department of Pathology, Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Circulating tumor cells (CTCs) recognition and characterization in the peripheral blood of patients with breast cancer have proven practical and predictive value in different studies. However, the clinical significance of CTCs enumeration and molecular characterization in thepersonalization of breast cancer diagnosis and treatment remains under the debate. A literature search in PubMed, Web of Science and Scopus was performed from October 1990 to June 2016 for studies which evaluating CTCs and its association with clinical and pathological characteristics and medical outcome in the field of breast cancer personalization for both diagnosis and treatment categories. The treatment outcomes were progression-free survival (PFS) and overall survival (OS) or relapse in different patients. Sixty-nine studies met the inclusion criteria. The sample size varies from 1 to 2026. Median follow-up was 15 months (range 3-27). Different molecular techniques have been applied toresearch, but they mostly are based on CTCs enrichment and then detection by using FDA-approved Cell SearchTM. By far the most studies define CTCs as cytokeratins (CK) positive and CD45 negative cells. Despite the differences in methodology, twenty-eight studies for breast cancer diagnosis and prognosis were mainly focused on CTCs isolation and enumeration.Forty-threeresearches were about CTCs count and exact molecular characterization. In the way of precision treatment, CTCs detection before starting the first-line of therapy or during therapy in breast cancer patients is extremely valuable, but in the way of precision medicine it should be supported with some molecular characteristics of CTCs like CTCs phenotypic changes, gene expression analysis of CTCs and molecular characteristics of CTCs.https://acta.tums.ac.ir/index.php/acta/article/view/6213Circulating tumor cellsBreast cancerPersonalized medicine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fatemeh Khatami Hamid Reza Aghayan Maryam Sanaei Ramin Heshmat Seyed Mohammad Tavangar Bagher Larijani |
spellingShingle |
Fatemeh Khatami Hamid Reza Aghayan Maryam Sanaei Ramin Heshmat Seyed Mohammad Tavangar Bagher Larijani The Potential of Circulating Tumor Cells in Personalized Management of Breast Cancer: A Systematic Review Acta Medica Iranica Circulating tumor cells Breast cancer Personalized medicine |
author_facet |
Fatemeh Khatami Hamid Reza Aghayan Maryam Sanaei Ramin Heshmat Seyed Mohammad Tavangar Bagher Larijani |
author_sort |
Fatemeh Khatami |
title |
The Potential of Circulating Tumor Cells in Personalized Management of Breast Cancer: A Systematic Review |
title_short |
The Potential of Circulating Tumor Cells in Personalized Management of Breast Cancer: A Systematic Review |
title_full |
The Potential of Circulating Tumor Cells in Personalized Management of Breast Cancer: A Systematic Review |
title_fullStr |
The Potential of Circulating Tumor Cells in Personalized Management of Breast Cancer: A Systematic Review |
title_full_unstemmed |
The Potential of Circulating Tumor Cells in Personalized Management of Breast Cancer: A Systematic Review |
title_sort |
potential of circulating tumor cells in personalized management of breast cancer: a systematic review |
publisher |
Tehran University of Medical Sciences |
series |
Acta Medica Iranica |
issn |
0044-6025 1735-9694 |
publishDate |
2017-03-01 |
description |
Circulating tumor cells (CTCs) recognition and characterization in the peripheral blood of patients with breast cancer have proven practical and predictive value in different studies. However, the clinical significance of CTCs enumeration and molecular characterization in thepersonalization of breast cancer diagnosis and treatment remains under the debate. A literature search in PubMed, Web of Science and Scopus was performed from October 1990 to June 2016 for studies which evaluating CTCs and its association with clinical and pathological characteristics and medical outcome in the field of breast cancer personalization for both diagnosis and treatment categories. The treatment outcomes were progression-free survival (PFS) and overall survival (OS) or relapse in different patients. Sixty-nine studies met the inclusion criteria. The sample size varies from 1 to 2026. Median follow-up was 15 months (range 3-27). Different molecular techniques have been applied toresearch, but they mostly are based on CTCs enrichment and then detection by using FDA-approved Cell SearchTM. By far the most studies define CTCs as cytokeratins (CK) positive and CD45 negative cells. Despite the differences in methodology, twenty-eight studies for breast cancer diagnosis and prognosis were mainly focused on CTCs isolation and enumeration.Forty-threeresearches were about CTCs count and exact molecular characterization. In the way of precision treatment, CTCs detection before starting the first-line of therapy or during therapy in breast cancer patients is extremely valuable, but in the way of precision medicine it should be supported with some molecular characteristics of CTCs like CTCs phenotypic changes, gene expression analysis of CTCs and molecular characteristics of CTCs. |
topic |
Circulating tumor cells Breast cancer Personalized medicine |
url |
https://acta.tums.ac.ir/index.php/acta/article/view/6213 |
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