Association between Serum Uric Acid Levels, Nutritional and Antioxidant Status in Patients on Hemodialysis
Purpose: To determine the relationship between uric acid (UA) and nutritional and antioxidant status in hemodialysis (HD) patients, given that hyperuricemia could be an indicator of good nutritional status possibly because of the antioxidant properties of UA. Methods: Cross-sectional study with 93 p...
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doaj-17f6400ef0634e59854141faff7a104d2020-11-25T03:41:11ZengMDPI AGNutrients2072-66432020-08-01122600260010.3390/nu12092600Association between Serum Uric Acid Levels, Nutritional and Antioxidant Status in Patients on HemodialysisEtna Domínguez-Zambrano0José Pedraza-Chaverri1Ana Laura López-Santos2Omar Noel Medina-Campos3Cristino Cruz-Rivera4Francisco Bueno-Hernández5Angeles Espinosa-Cuevas6Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutricion Salvador Zubirán, México City PC 14080, MexicoChemistry Faculty, Universidad Nacional Autónoma de México, México City ZC 04510, MexicoDepartment of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutricion Salvador Zubirán, México City PC 14080, MexicoChemistry Faculty, Universidad Nacional Autónoma de México, México City ZC 04510, MexicoDepartment of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutricion Salvador Zubirán, México City PC 14080, MexicoCentro de Atención Renal, Estado de México ZC 53100, MexicoDepartment of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutricion Salvador Zubirán, México City PC 14080, MexicoPurpose: To determine the relationship between uric acid (UA) and nutritional and antioxidant status in hemodialysis (HD) patients, given that hyperuricemia could be an indicator of good nutritional status possibly because of the antioxidant properties of UA. Methods: Cross-sectional study with 93 patients on HD. Hyperuricemia was considered as UA ≥6.0 mg/dL in females and ≥7.0 mg/dL in males. Nutritional variables were registered. Blood samples were taken before the dialysis session to determine oxidative damage as plasma malondialdehyde (MDA) content, and antioxidant capacity measuring 2,2-diphenyl-piclrylhidrazil radical (DPPH<sup>●</sup>) scavenging activity and oxygen radical absorbance capacity (ORAC) value. Results: Patients with hyperuricemia had higher creatinine (11.9 vs. 10.5 mg/dL; <i>p</i> = 0.004), potassium (5.5 vs. 5.0 mg/dL; <i>p</i> = 0.014) levels; phase angle (5.8 vs. 4.9; <i>p</i> = 0.005), protein consumption (normalized protein nitrogen appearance, nPNA, 1.03 vs. 0.83; <i>p</i> = 0.013) than normouricemic patients. DPPH<sup>●</sup> scavenging activity was higher in hyperuricemic subjects (1.139 vs. 1.049 mM Trolox equivalents; <i>p</i> = 0.007); likewise, hyperuricemic subjects had less oxidant damage measured by MDA (10.6 vs. 12.7 nmol/mL; <i>p</i> = 0.020). Subjects with normouricemia were at higher risk of having a reactance to height (Xc/H) ratio less than 35 (OR 2.79; 95% CI, 1.1–7.017, <i>p</i> = 0.028); nPNA < 1.0 (OR 3.78; 95% CI, 1.4–10.2, <i>p</i> = 0.007), diagnosis of cachexia (OR 2.95; 95% CI, 1156–7.518, <i>p</i> = 0.021), potassium levels <5 (OR 2.97; 95% CI, 1.136–7.772, <i>p</i> = 0.023) and PA < 5.5° (OR 3.38; 95% CI, 1.309–8.749, <i>p</i> = 0.012.) Conclusions: Patients with hyperuricemia had higher antioxidant capacity and better nutritional status. Purines and protein restrictions in HD patients with hyperuricemia need to be reviewed individually for each patient. More studies are needed to stablish a cut point of UA levels in renal population.https://www.mdpi.com/2072-6643/12/9/2600uric acidnutritional statusrenal dialysisoxidative stressmalondialdehydeoxygen radical absorbance capacity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Etna Domínguez-Zambrano José Pedraza-Chaverri Ana Laura López-Santos Omar Noel Medina-Campos Cristino Cruz-Rivera Francisco Bueno-Hernández Angeles Espinosa-Cuevas |
spellingShingle |
Etna Domínguez-Zambrano José Pedraza-Chaverri Ana Laura López-Santos Omar Noel Medina-Campos Cristino Cruz-Rivera Francisco Bueno-Hernández Angeles Espinosa-Cuevas Association between Serum Uric Acid Levels, Nutritional and Antioxidant Status in Patients on Hemodialysis Nutrients uric acid nutritional status renal dialysis oxidative stress malondialdehyde oxygen radical absorbance capacity |
author_facet |
Etna Domínguez-Zambrano José Pedraza-Chaverri Ana Laura López-Santos Omar Noel Medina-Campos Cristino Cruz-Rivera Francisco Bueno-Hernández Angeles Espinosa-Cuevas |
author_sort |
Etna Domínguez-Zambrano |
title |
Association between Serum Uric Acid Levels, Nutritional and Antioxidant Status in Patients on Hemodialysis |
title_short |
Association between Serum Uric Acid Levels, Nutritional and Antioxidant Status in Patients on Hemodialysis |
title_full |
Association between Serum Uric Acid Levels, Nutritional and Antioxidant Status in Patients on Hemodialysis |
title_fullStr |
Association between Serum Uric Acid Levels, Nutritional and Antioxidant Status in Patients on Hemodialysis |
title_full_unstemmed |
Association between Serum Uric Acid Levels, Nutritional and Antioxidant Status in Patients on Hemodialysis |
title_sort |
association between serum uric acid levels, nutritional and antioxidant status in patients on hemodialysis |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2020-08-01 |
description |
Purpose: To determine the relationship between uric acid (UA) and nutritional and antioxidant status in hemodialysis (HD) patients, given that hyperuricemia could be an indicator of good nutritional status possibly because of the antioxidant properties of UA. Methods: Cross-sectional study with 93 patients on HD. Hyperuricemia was considered as UA ≥6.0 mg/dL in females and ≥7.0 mg/dL in males. Nutritional variables were registered. Blood samples were taken before the dialysis session to determine oxidative damage as plasma malondialdehyde (MDA) content, and antioxidant capacity measuring 2,2-diphenyl-piclrylhidrazil radical (DPPH<sup>●</sup>) scavenging activity and oxygen radical absorbance capacity (ORAC) value. Results: Patients with hyperuricemia had higher creatinine (11.9 vs. 10.5 mg/dL; <i>p</i> = 0.004), potassium (5.5 vs. 5.0 mg/dL; <i>p</i> = 0.014) levels; phase angle (5.8 vs. 4.9; <i>p</i> = 0.005), protein consumption (normalized protein nitrogen appearance, nPNA, 1.03 vs. 0.83; <i>p</i> = 0.013) than normouricemic patients. DPPH<sup>●</sup> scavenging activity was higher in hyperuricemic subjects (1.139 vs. 1.049 mM Trolox equivalents; <i>p</i> = 0.007); likewise, hyperuricemic subjects had less oxidant damage measured by MDA (10.6 vs. 12.7 nmol/mL; <i>p</i> = 0.020). Subjects with normouricemia were at higher risk of having a reactance to height (Xc/H) ratio less than 35 (OR 2.79; 95% CI, 1.1–7.017, <i>p</i> = 0.028); nPNA < 1.0 (OR 3.78; 95% CI, 1.4–10.2, <i>p</i> = 0.007), diagnosis of cachexia (OR 2.95; 95% CI, 1156–7.518, <i>p</i> = 0.021), potassium levels <5 (OR 2.97; 95% CI, 1.136–7.772, <i>p</i> = 0.023) and PA < 5.5° (OR 3.38; 95% CI, 1.309–8.749, <i>p</i> = 0.012.) Conclusions: Patients with hyperuricemia had higher antioxidant capacity and better nutritional status. Purines and protein restrictions in HD patients with hyperuricemia need to be reviewed individually for each patient. More studies are needed to stablish a cut point of UA levels in renal population. |
topic |
uric acid nutritional status renal dialysis oxidative stress malondialdehyde oxygen radical absorbance capacity |
url |
https://www.mdpi.com/2072-6643/12/9/2600 |
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