Chinese herbal medicine SS-1 inhibits T cell activation and abrogates TH responses in Sjögren's syndrome
Background/Purpose: Sjögren's syndrome (SS) is an autoimmune disease and its conventional treatment has exhibited limited therapeutic efficacy. Traditional Chinese medicine has been demonstrated to ameliorate the sicca symptoms of SS by decreasing the level of TH1 and TH2 cytokines and increasi...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-01-01
|
Series: | Journal of the Formosan Medical Association |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664620303363 |
id |
doaj-1805a431837c44d8b87c37dd904432a9 |
---|---|
record_format |
Article |
spelling |
doaj-1805a431837c44d8b87c37dd904432a92020-12-17T04:46:42ZengElsevierJournal of the Formosan Medical Association0929-66462021-01-011201651659Chinese herbal medicine SS-1 inhibits T cell activation and abrogates TH responses in Sjögren's syndromeGilbert Aaron Lee0Ching-Mao Chang1Ying Chieh Wu2Ruo-yu Ma3Cheng-Yu Chen4Yin-Tzu Hsue5Nan-Shih Liao6Hen-Hong Chang7Department of Medical Research, Taipei Medical University Hospital, Taipei, TaiwanCenter for Traditional Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Faculty of Medicine, National Yang-Ming University, Taipei, TaiwanDepartment of Medical Research, Taipei Medical University Hospital, Taipei, TaiwanInstitute of Molecular Biology, Academia Sinica, Taipei, TaiwanDepartment of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanDivision of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, TaiwanInstitute of Molecular Biology, Academia Sinica, Taipei, Taiwan; Corresponding author. Institute of Molecular Biology, Academia Sinica, No.128 Academia Road, Section 2, Nankang, Taipei, 11529, Taiwan. Fax: +886 2 2782 6085.Graduate Institute of Integrated Medicine, and Graduate Institute of Acupuncture Science, College of Chinese Medicine, and Chinese Medicine Research Center, China Medical University, Taichung, Taiwan; Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan; Corresponding author. Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, No. 91, Hsueh-Shih Road, Taichung, 40402, Taiwan. Fax: +886 4 2203 7690.Background/Purpose: Sjögren's syndrome (SS) is an autoimmune disease and its conventional treatment has exhibited limited therapeutic efficacy. Traditional Chinese medicine has been demonstrated to ameliorate the sicca symptoms of SS by decreasing the level of TH1 and TH2 cytokines and increasing salivary flow rate. A newly designed traditional Chinese medicine, SS-1, showed improved efficacy in alleviating the dryness symptoms of SS patients in the National Taiwan SS cohort investigation. Here, we investigated the effect of SS-1 on T cell responses. Methods: SS-1 was authenticated and its major compounds were verified by high-performance liquid chromatography. We examined the effects of SS-1 on the activation and TH1, TH2, and TH17 polarization of murine T cells. We also determined the level of TH1, TH2, and TH17 cytokine RNA in peripheral blood mononuclear cells of SS patients before and after SS-1 treatment. Results: SS-1 treatment inhibits the activation and TH1, TH2, and IL-17A+IFNγ+ TH polarization of murine T cells. SS-1 treatment also significantly reduces IFN-γ, IL-4, and IL-13 expression, and moderately reduces IL-17A expression in peripheral blood mononuclear cells of SS patients. Conclusion: Our results suggest that SS-1 inhibits T cell activation and diminishes TH1, TH2, and IL-17+IFN-γ+ TH responses in SS patients.http://www.sciencedirect.com/science/article/pii/S0929664620303363Sjögren's syndromeTraditional Chinese medicineT cell activationTH response |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gilbert Aaron Lee Ching-Mao Chang Ying Chieh Wu Ruo-yu Ma Cheng-Yu Chen Yin-Tzu Hsue Nan-Shih Liao Hen-Hong Chang |
spellingShingle |
Gilbert Aaron Lee Ching-Mao Chang Ying Chieh Wu Ruo-yu Ma Cheng-Yu Chen Yin-Tzu Hsue Nan-Shih Liao Hen-Hong Chang Chinese herbal medicine SS-1 inhibits T cell activation and abrogates TH responses in Sjögren's syndrome Journal of the Formosan Medical Association Sjögren's syndrome Traditional Chinese medicine T cell activation TH response |
author_facet |
Gilbert Aaron Lee Ching-Mao Chang Ying Chieh Wu Ruo-yu Ma Cheng-Yu Chen Yin-Tzu Hsue Nan-Shih Liao Hen-Hong Chang |
author_sort |
Gilbert Aaron Lee |
title |
Chinese herbal medicine SS-1 inhibits T cell activation and abrogates TH responses in Sjögren's syndrome |
title_short |
Chinese herbal medicine SS-1 inhibits T cell activation and abrogates TH responses in Sjögren's syndrome |
title_full |
Chinese herbal medicine SS-1 inhibits T cell activation and abrogates TH responses in Sjögren's syndrome |
title_fullStr |
Chinese herbal medicine SS-1 inhibits T cell activation and abrogates TH responses in Sjögren's syndrome |
title_full_unstemmed |
Chinese herbal medicine SS-1 inhibits T cell activation and abrogates TH responses in Sjögren's syndrome |
title_sort |
chinese herbal medicine ss-1 inhibits t cell activation and abrogates th responses in sjögren's syndrome |
publisher |
Elsevier |
series |
Journal of the Formosan Medical Association |
issn |
0929-6646 |
publishDate |
2021-01-01 |
description |
Background/Purpose: Sjögren's syndrome (SS) is an autoimmune disease and its conventional treatment has exhibited limited therapeutic efficacy. Traditional Chinese medicine has been demonstrated to ameliorate the sicca symptoms of SS by decreasing the level of TH1 and TH2 cytokines and increasing salivary flow rate. A newly designed traditional Chinese medicine, SS-1, showed improved efficacy in alleviating the dryness symptoms of SS patients in the National Taiwan SS cohort investigation. Here, we investigated the effect of SS-1 on T cell responses. Methods: SS-1 was authenticated and its major compounds were verified by high-performance liquid chromatography. We examined the effects of SS-1 on the activation and TH1, TH2, and TH17 polarization of murine T cells. We also determined the level of TH1, TH2, and TH17 cytokine RNA in peripheral blood mononuclear cells of SS patients before and after SS-1 treatment. Results: SS-1 treatment inhibits the activation and TH1, TH2, and IL-17A+IFNγ+ TH polarization of murine T cells. SS-1 treatment also significantly reduces IFN-γ, IL-4, and IL-13 expression, and moderately reduces IL-17A expression in peripheral blood mononuclear cells of SS patients. Conclusion: Our results suggest that SS-1 inhibits T cell activation and diminishes TH1, TH2, and IL-17+IFN-γ+ TH responses in SS patients. |
topic |
Sjögren's syndrome Traditional Chinese medicine T cell activation TH response |
url |
http://www.sciencedirect.com/science/article/pii/S0929664620303363 |
work_keys_str_mv |
AT gilbertaaronlee chineseherbalmediciness1inhibitstcellactivationandabrogatesthresponsesinsjogrenssyndrome AT chingmaochang chineseherbalmediciness1inhibitstcellactivationandabrogatesthresponsesinsjogrenssyndrome AT yingchiehwu chineseherbalmediciness1inhibitstcellactivationandabrogatesthresponsesinsjogrenssyndrome AT ruoyuma chineseherbalmediciness1inhibitstcellactivationandabrogatesthresponsesinsjogrenssyndrome AT chengyuchen chineseherbalmediciness1inhibitstcellactivationandabrogatesthresponsesinsjogrenssyndrome AT yintzuhsue chineseherbalmediciness1inhibitstcellactivationandabrogatesthresponsesinsjogrenssyndrome AT nanshihliao chineseherbalmediciness1inhibitstcellactivationandabrogatesthresponsesinsjogrenssyndrome AT henhongchang chineseherbalmediciness1inhibitstcellactivationandabrogatesthresponsesinsjogrenssyndrome |
_version_ |
1724380509241344000 |