Dual Inhibitors Targeting DNA and Histone Deacetylases

Dual Inhibitors Targeting DNA and Histone Deacetylases

Histone deacetylases (HDACs) regulate the acetylation status of histones and structural status of chromatin. The chromatin structure becomes relaxed after inhibition of HDAC, leading to DNA exposed to DNA disrupting agents, and eventually causing DNA dysfunction. Recently, more and more dual inhibit...

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Bibliographic Details
Main Authors:	Chen Chen, Xinying Yang, Xuben Hou, Hao Fang
Format:	Article
Language:	English
Published:	Georg Thieme Verlag KG 2020-06-01
Series:	Pharmaceutical Fronts
Subjects:	dna hdac dual-targeting antitumor agent
Online Access:	http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1713873

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