TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy

TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy

Xenophage, or autophagy directed against pathogens, might be involved in the clearance of bacterial infection, but the mechanism is unclear. Here, the authors show that ubiquitinated bacteria are bound by TBC1D9 via a Ca2+-dependent interaction to induce downstream activation of TBK1 signalling and...

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Bibliographic Details
Main Authors: Takashi Nozawa, Shunsuke Sano, Atsuko Minowa-Nozawa, Hirotaka Toh, Shintaro Nakajima, Kazunori Murase, Chihiro Aikawa, Ichiro Nakagawa
Format: Article
Language:English
Published: Nature Publishing Group 2020-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14533-4
Description
Summary:Xenophage, or autophagy directed against pathogens, might be involved in the clearance of bacterial infection, but the mechanism is unclear. Here, the authors show that ubiquitinated bacteria are bound by TBC1D9 via a Ca2+-dependent interaction to induce downstream activation of TBK1 signalling and xenophagy, as well as mitophagy.
ISSN:2041-1723

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