Design, synthesis, and biological evaluation of a multifunctional neuropeptide-Y conjugate for selective nuclear delivery of radiolanthanides

Design, synthesis, and biological evaluation of a multifunctional neuropeptide-Y conjugate for selective nuclear delivery of radiolanthanides

Abstract Background Targeting G protein-coupled receptors on the surface of cancer cells with peptide ligands is a promising concept for the selective tumor delivery of therapeutically active cargos, including radiometals for targeted radionuclide therapy (TRT). Recently, the radiolanthanide terbium...

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Bibliographic Details
Main Authors: Adrien Chastel, Dennis J. Worm, Isabel D. Alves, Delphine Vimont, Melina Petrel, Samantha Fernandez, Philippe Garrigue, Philippe Fernandez, Elif Hindié, Annette G. Beck-Sickinger, Clément Morgat
Format: Article
Language:English
Published: SpringerOpen 2020-03-01
Series:EJNMMI Research
Subjects:
161Tb
Neuropeptide-Y
Sub-cellular delivery
Auger-emitter
Breast cancer
Online Access:http://link.springer.com/article/10.1186/s13550-020-0612-8

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