Magnesium uptake by connecting fluid-phase endocytosis to an intracellular inorganic cation filter

Magnesium uptake by connecting fluid-phase endocytosis to an intracellular inorganic cation filter

Metal bioavailability is frequently limited by sequestering agents which makes them inaccessible to cells. Here the authors show that cells can increase Mg2+ uptake via fluid phase endocytosis and accumulate this metal in their vacuole loaded with polyphosphate, and later can be exported to the cyto...

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Bibliographic Details
Main Authors: Sandra H. Klompmaker, Kid Kohl, Nicolas Fasel, Andreas Mayer
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01930-5
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spelling doaj-182bfaf9f5b64f8ab6a9e7760493db682021-05-11T07:04:01ZengNature Publishing GroupNature Communications2041-17232017-12-018111210.1038/s41467-017-01930-5Magnesium uptake by connecting fluid-phase endocytosis to an intracellular inorganic cation filterSandra H. Klompmaker0Kid Kohl1Nicolas Fasel2Andreas Mayer3Department of Biochemistry, University of LausanneDepartment of Biochemistry, University of LausanneDepartment of Biochemistry, University of LausanneDepartment of Biochemistry, University of LausanneMetal bioavailability is frequently limited by sequestering agents which makes them inaccessible to cells. Here the authors show that cells can increase Mg2+ uptake via fluid phase endocytosis and accumulate this metal in their vacuole loaded with polyphosphate, and later can be exported to the cytosol.https://doi.org/10.1038/s41467-017-01930-5
collection DOAJ
language English
format Article
sources DOAJ
author Sandra H. Klompmaker
Kid Kohl
Nicolas Fasel
Andreas Mayer
spellingShingle Sandra H. Klompmaker
Kid Kohl
Nicolas Fasel
Andreas Mayer
Magnesium uptake by connecting fluid-phase endocytosis to an intracellular inorganic cation filter
Nature Communications
author_facet Sandra H. Klompmaker
Kid Kohl
Nicolas Fasel
Andreas Mayer
author_sort Sandra H. Klompmaker
title Magnesium uptake by connecting fluid-phase endocytosis to an intracellular inorganic cation filter
title_short Magnesium uptake by connecting fluid-phase endocytosis to an intracellular inorganic cation filter
title_full Magnesium uptake by connecting fluid-phase endocytosis to an intracellular inorganic cation filter
title_fullStr Magnesium uptake by connecting fluid-phase endocytosis to an intracellular inorganic cation filter
title_full_unstemmed Magnesium uptake by connecting fluid-phase endocytosis to an intracellular inorganic cation filter
title_sort magnesium uptake by connecting fluid-phase endocytosis to an intracellular inorganic cation filter
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-12-01
description Metal bioavailability is frequently limited by sequestering agents which makes them inaccessible to cells. Here the authors show that cells can increase Mg2+ uptake via fluid phase endocytosis and accumulate this metal in their vacuole loaded with polyphosphate, and later can be exported to the cytosol.
url https://doi.org/10.1038/s41467-017-01930-5
work_keys_str_mv AT sandrahklompmaker magnesiumuptakebyconnectingfluidphaseendocytosistoanintracellularinorganiccationfilter
AT kidkohl magnesiumuptakebyconnectingfluidphaseendocytosistoanintracellularinorganiccationfilter
AT nicolasfasel magnesiumuptakebyconnectingfluidphaseendocytosistoanintracellularinorganiccationfilter
AT andreasmayer magnesiumuptakebyconnectingfluidphaseendocytosistoanintracellularinorganiccationfilter
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