Aspectos genéticos do transtorno obsessivo-compulsivo

• Main Author: Gonzalez Christina H
• Format: Article
• Language: English
• Published: Associação Brasileira de Psiquiatria (ABP) 2001-01-01
• Series: Brazilian Journal of Psychiatry
• Subjects: Obsessive-compulsive disorder; Etiology; Genetics; Genetic predisposition to disease
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462001000600012

Since the first descriptions of obsessive-compulsive disorder (OCD), genetic factors have been implicated in the etiology of the illness. Twin studies show a high concordance rate for monozygotic twins. Family studies found a higher risk for OCD among relatives of OCD patients. Segregation analysis studies suggest the possible role of a major effect gene in the etiology of OCD. Association studies using molecular techniques have been conducted to try to find a specific gene or polymorphism involved in OCD. This review outlines the evidence gathered to date, including the recent findings in the molecular genetics analysis.