Increased Serum Leptin Level Predicts Bone Mineral Density in Hemodialysis Patients
Background. Leptin acts through the adipose-bone axis to regulate bone mineral density (BMD). This study evaluated the relationship between BMD and serum leptin levels in patients on hemodialysis. Methods. In this cross-sectional study including 98 hemodialysis patients, BMD was measured using dual...
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doaj-184877f909e242f98415c8c64a94a5822020-11-25T03:13:29ZengHindawi LimitedInternational Journal of Endocrinology1687-83371687-83452020-01-01202010.1155/2020/84517518451751Increased Serum Leptin Level Predicts Bone Mineral Density in Hemodialysis PatientsChih-Hsien Wang0Yu-Hsien Lai1Yu-Li Lin2Chiu-Huang Kuo3Ru-Jiang Syu4Ming-Chun Chen5Bang-Gee Hsu6Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, TaiwanDivision of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, TaiwanDivision of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, TaiwanDivision of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, TaiwanDivision of Nephrology, Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 62247, TaiwanSchool of Medicine, Tzu Chi University, Hualien, TaiwanDivision of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, TaiwanBackground. Leptin acts through the adipose-bone axis to regulate bone mineral density (BMD). This study evaluated the relationship between BMD and serum leptin levels in patients on hemodialysis. Methods. In this cross-sectional study including 98 hemodialysis patients, BMD was measured using dual energy X-ray absorptiometry of the lumbar vertebrae (L2–L4), and serum leptin levels were determined using an enzyme immunoassay. Results. There were 25 (25.5%), 13 (13.3%), and 60 (61.2%) patients with osteopenia, osteoporosis, and normal BMD, respectively. Advanced age P=0.017; decreased body mass index (BMI, P<0.001); body height P<0.001; prehemodialysis body weight (BW, P<0.001); post-hemodialysis BW P<0.001; waist circumference P<0.001; and triglyceride P=0.015, albumin P=0.004, and leptin levels P=0.017 were associated with lower lumbar T scores, whereas increased urea reduction rate (URR, P=0.004) and fractional clearance index for urea (Kt/V, P=0.004) were associated with lower lumbar T scores. The multivariable forward stepwise linear regression analysis with adjustment for sex; age; body height; prehemodialysis BW; BMI; waist circumference; logarithmically transformed triglycerides (log-triglycerides), albumin, creatinine, and leptin (log-leptin) levels; URR; and Kt/V indicated that high serum level of log-leptin (R2 change = 0.184; P<0.001), increased prehemodialysis BW (R2 change = 0.325; P=0.008), male sex (R2 change = 0.048; P=0.001), young age (R2 change = 0.044; P=0.012), and increased serum albumin level (R2 change = 0.017; P=0.044) were significantly and independently associated with lumbar BMD. Conclusions. Advanced age and female sex were associated with poor BMD, whereas increased BW, serum albumin, and leptin levels were positively associated with BMD in patients on hemodialysis.http://dx.doi.org/10.1155/2020/8451751 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chih-Hsien Wang Yu-Hsien Lai Yu-Li Lin Chiu-Huang Kuo Ru-Jiang Syu Ming-Chun Chen Bang-Gee Hsu |
spellingShingle |
Chih-Hsien Wang Yu-Hsien Lai Yu-Li Lin Chiu-Huang Kuo Ru-Jiang Syu Ming-Chun Chen Bang-Gee Hsu Increased Serum Leptin Level Predicts Bone Mineral Density in Hemodialysis Patients International Journal of Endocrinology |
author_facet |
Chih-Hsien Wang Yu-Hsien Lai Yu-Li Lin Chiu-Huang Kuo Ru-Jiang Syu Ming-Chun Chen Bang-Gee Hsu |
author_sort |
Chih-Hsien Wang |
title |
Increased Serum Leptin Level Predicts Bone Mineral Density in Hemodialysis Patients |
title_short |
Increased Serum Leptin Level Predicts Bone Mineral Density in Hemodialysis Patients |
title_full |
Increased Serum Leptin Level Predicts Bone Mineral Density in Hemodialysis Patients |
title_fullStr |
Increased Serum Leptin Level Predicts Bone Mineral Density in Hemodialysis Patients |
title_full_unstemmed |
Increased Serum Leptin Level Predicts Bone Mineral Density in Hemodialysis Patients |
title_sort |
increased serum leptin level predicts bone mineral density in hemodialysis patients |
publisher |
Hindawi Limited |
series |
International Journal of Endocrinology |
issn |
1687-8337 1687-8345 |
publishDate |
2020-01-01 |
description |
Background. Leptin acts through the adipose-bone axis to regulate bone mineral density (BMD). This study evaluated the relationship between BMD and serum leptin levels in patients on hemodialysis. Methods. In this cross-sectional study including 98 hemodialysis patients, BMD was measured using dual energy X-ray absorptiometry of the lumbar vertebrae (L2–L4), and serum leptin levels were determined using an enzyme immunoassay. Results. There were 25 (25.5%), 13 (13.3%), and 60 (61.2%) patients with osteopenia, osteoporosis, and normal BMD, respectively. Advanced age P=0.017; decreased body mass index (BMI, P<0.001); body height P<0.001; prehemodialysis body weight (BW, P<0.001); post-hemodialysis BW P<0.001; waist circumference P<0.001; and triglyceride P=0.015, albumin P=0.004, and leptin levels P=0.017 were associated with lower lumbar T scores, whereas increased urea reduction rate (URR, P=0.004) and fractional clearance index for urea (Kt/V, P=0.004) were associated with lower lumbar T scores. The multivariable forward stepwise linear regression analysis with adjustment for sex; age; body height; prehemodialysis BW; BMI; waist circumference; logarithmically transformed triglycerides (log-triglycerides), albumin, creatinine, and leptin (log-leptin) levels; URR; and Kt/V indicated that high serum level of log-leptin (R2 change = 0.184; P<0.001), increased prehemodialysis BW (R2 change = 0.325; P=0.008), male sex (R2 change = 0.048; P=0.001), young age (R2 change = 0.044; P=0.012), and increased serum albumin level (R2 change = 0.017; P=0.044) were significantly and independently associated with lumbar BMD. Conclusions. Advanced age and female sex were associated with poor BMD, whereas increased BW, serum albumin, and leptin levels were positively associated with BMD in patients on hemodialysis. |
url |
http://dx.doi.org/10.1155/2020/8451751 |
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