REG-O3 chimeric peptide combining growth hormone and somatostatin sequences improves joint function and prevents cartilage degradation in rat model of traumatic knee osteoarthritis.
OBJECTIVE:REG-O3 is a 24-aminoacid chimeric peptide combining a sequence derived from growth hormone (GH) and an analog of somatostatin (SST), molecules displaying cartilage repair and anti-inflammatory properties, respectively. This study aimed to investigate the disease-modifying osteoarthritis dr...
Main Authors: | Rodrick Montjean, Sonia Escaich, Raffaello Paolini, Claude Carelli, Sébastien Pirson, Thibaut Neutelings, Yves Henrotin, Christelle Vêtu |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2020-01-01
|
Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0231240 |
Similar Items
-
Oral supplementation with fish cartilage hydrolysate accelerates joint function recovery in rat model of traumatic knee osteoarthritis
by: Yves Henrotin, et al.
Published: (2021-06-01) -
Avocado/Soybean Unsaponifiables (Piacledine®300) show beneficial effect on the metabolism of osteoarthritic cartilage, synovium and subchondral bone: An overview of the mechanisms
by: Yves Edgard Henrotin
Published: (2017-12-01) -
Somatostatin-Dopamine Chimeric Molecules in Neuroendocrine Neoplasms
by: Maria Celeste Cantone, et al.
Published: (2021-02-01) -
The Damage-Associated Molecular Patterns (DAMPs) as Potential Targets to Treat Osteoarthritis: Perspectives From a Review of the Literature
by: Cécile Lambert, et al.
Published: (2021-01-01) -
Cartilage and knee osteoarthritis
by: Alejandro Alvarez-López, et al.
Published: (2019-11-01)