ABCG2 gene polymorphism rs2231142 is associated with gout comorbidities but not allopurinol response in primary gout patients of a Chinese Han male population
Abstract Background One common ATP-binding cassette subfamily G member 2 (ABCG2) gene variant, which is encoded by the single nucleotide polymorphism (SNP) rs2231142, was identified to take an essential part in gouty arthritis. However, the relationship between rs2231142, gout comorbidities and ther...
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Online Access: | http://link.springer.com/article/10.1186/s41065-019-0103-y |
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doaj-1864a7480c9b462c88b37779b34ba9432020-11-25T03:47:10ZengBMCHereditas1601-52232019-07-0115611710.1186/s41065-019-0103-yABCG2 gene polymorphism rs2231142 is associated with gout comorbidities but not allopurinol response in primary gout patients of a Chinese Han male populationKeke Zhang0Changgui Li1Qingdao UniversityQingdao UniversityAbstract Background One common ATP-binding cassette subfamily G member 2 (ABCG2) gene variant, which is encoded by the single nucleotide polymorphism (SNP) rs2231142, was identified to take an essential part in gouty arthritis. However, the relationship between rs2231142, gout comorbidities and therapeutic effect of allopurinol in Chinese Han male population is still unclear. Wherefore, this study explored into the association between ABCG2 SNP rs2231142 affecting common comorbidities and the therapeutic effect of allopurinol in Chinese Han male gout patients. Results ABCG2 SNP rs2231142 and the gout comorbidities including nephrolithiasis and CKD were associated (P = 0.014 and P = 0.026). Group CKD stage = 1 were significantly different from those in group CKD stage≥2 regarding genotypes of ABCG2 gene polymorphism, while they were not significantly different from those in group CKD stage≥3. Meanwhile, the genotypes of rs2231142 and allopurinol response were not significantly associated (P = 0.588). Conclusions ABCG2 rs2231142 may predict the risk of kidney comorbidities for Chinese Han male gout patients, but not allopurinol response.http://link.springer.com/article/10.1186/s41065-019-0103-yGoutABCG2PolymorphismsAllopurinol |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Keke Zhang Changgui Li |
spellingShingle |
Keke Zhang Changgui Li ABCG2 gene polymorphism rs2231142 is associated with gout comorbidities but not allopurinol response in primary gout patients of a Chinese Han male population Hereditas Gout ABCG2 Polymorphisms Allopurinol |
author_facet |
Keke Zhang Changgui Li |
author_sort |
Keke Zhang |
title |
ABCG2 gene polymorphism rs2231142 is associated with gout comorbidities but not allopurinol response in primary gout patients of a Chinese Han male population |
title_short |
ABCG2 gene polymorphism rs2231142 is associated with gout comorbidities but not allopurinol response in primary gout patients of a Chinese Han male population |
title_full |
ABCG2 gene polymorphism rs2231142 is associated with gout comorbidities but not allopurinol response in primary gout patients of a Chinese Han male population |
title_fullStr |
ABCG2 gene polymorphism rs2231142 is associated with gout comorbidities but not allopurinol response in primary gout patients of a Chinese Han male population |
title_full_unstemmed |
ABCG2 gene polymorphism rs2231142 is associated with gout comorbidities but not allopurinol response in primary gout patients of a Chinese Han male population |
title_sort |
abcg2 gene polymorphism rs2231142 is associated with gout comorbidities but not allopurinol response in primary gout patients of a chinese han male population |
publisher |
BMC |
series |
Hereditas |
issn |
1601-5223 |
publishDate |
2019-07-01 |
description |
Abstract Background One common ATP-binding cassette subfamily G member 2 (ABCG2) gene variant, which is encoded by the single nucleotide polymorphism (SNP) rs2231142, was identified to take an essential part in gouty arthritis. However, the relationship between rs2231142, gout comorbidities and therapeutic effect of allopurinol in Chinese Han male population is still unclear. Wherefore, this study explored into the association between ABCG2 SNP rs2231142 affecting common comorbidities and the therapeutic effect of allopurinol in Chinese Han male gout patients. Results ABCG2 SNP rs2231142 and the gout comorbidities including nephrolithiasis and CKD were associated (P = 0.014 and P = 0.026). Group CKD stage = 1 were significantly different from those in group CKD stage≥2 regarding genotypes of ABCG2 gene polymorphism, while they were not significantly different from those in group CKD stage≥3. Meanwhile, the genotypes of rs2231142 and allopurinol response were not significantly associated (P = 0.588). Conclusions ABCG2 rs2231142 may predict the risk of kidney comorbidities for Chinese Han male gout patients, but not allopurinol response. |
topic |
Gout ABCG2 Polymorphisms Allopurinol |
url |
http://link.springer.com/article/10.1186/s41065-019-0103-y |
work_keys_str_mv |
AT kekezhang abcg2genepolymorphismrs2231142isassociatedwithgoutcomorbiditiesbutnotallopurinolresponseinprimarygoutpatientsofachinesehanmalepopulation AT changguili abcg2genepolymorphismrs2231142isassociatedwithgoutcomorbiditiesbutnotallopurinolresponseinprimarygoutpatientsofachinesehanmalepopulation |
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1724503195207598080 |