m6A RNA modification and its writer/reader VIRMA/YTHDF3 in testicular germ cell tumors: a role in seminoma phenotype maintenance

m6A RNA modification and its writer/reader VIRMA/YTHDF3 in testicular germ cell tumors: a role in seminoma phenotype maintenance

Abstract Background Covalent RNA modifications, such as N-6-methyladenosine (m6A), have been associated with various biological processes, but their role in cancer remains largely unexplored. m6A dynamics depends on specific enzymes whose deregulation may also impact in tumorigenesis. Herein, we ass...

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Bibliographic Details
Main Authors: João Lobo, Ana Laura Costa, Mariana Cantante, Rita Guimarães, Paula Lopes, Luís Antunes, Isaac Braga, Jorge Oliveira, Mattia Pelizzola, Rui Henrique, Carmen Jerónimo
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Journal of Translational Medicine
Subjects:
Epitranscriptomics
M6A
RNA
Testicular germ-cell tumors
VIRMA
YTHDF3
Online Access:http://link.springer.com/article/10.1186/s12967-019-1837-z

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