Noninvasive Indirect Markers of Liver Fibrosis in Alcoholics
The aim of this study was to evaluate the diagnostic values of noninvasive indirect markers of liver fibrosis: APRI, GAPRI, Forns, FIB-4, Age-Platelet, and Hepascore in alcoholics. Blood samples were collected from a randomized group of 142 alcohol-dependent patients. The diagnosis of dependency was...
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Online Access: | http://dx.doi.org/10.1155/2019/3646975 |
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doaj-188eeb1589094972b83a38c7f54791a62020-11-25T01:37:18ZengHindawi LimitedBioMed Research International2314-61332314-61412019-01-01201910.1155/2019/36469753646975Noninvasive Indirect Markers of Liver Fibrosis in AlcoholicsLech Chrostek0Dagmara Przekop1Ewa Gruszewska2Monika Gudowska-Sawczuk3Bogdan Cylwik4Department of Biochemical Diagnostics, Medical University of Bialystok, Waszyngtona 15A, 15-269 Bialystok, PolandDepartment of Biochemical Diagnostics, Medical University of Bialystok, Waszyngtona 15A, 15-269 Bialystok, PolandDepartment of Biochemical Diagnostics, Medical University of Bialystok, Waszyngtona 15A, 15-269 Bialystok, PolandDepartment of Biochemical Diagnostics, Medical University of Bialystok, Waszyngtona 15A, 15-269 Bialystok, PolandDepartment of Pediatric Laboratory Diagnostics, Medical University of Bialystok, Waszyngtona 17, 15-274 Bialystok, PolandThe aim of this study was to evaluate the diagnostic values of noninvasive indirect markers of liver fibrosis: APRI, GAPRI, Forns, FIB-4, Age-Platelet, and Hepascore in alcoholics. Blood samples were collected from a randomized group of 142 alcohol-dependent patients. The diagnosis of dependency was made according to the ICD-10 WHO criteria. The values of noninvasive markers were calculated with specific algorithms. The fibrosis stage was evaluated on the basis of FibroTest. The values of APRI, Forns, FIB-4, GAPRI, AP, and Hepascore differ between various stages of liver fibrosis. Patients with fibrosis stage F0 present lower values of APRI, Forns, FIB-4, GAPRI, and Hepascore in comparison to the patients with stages F1 and F0-F1. Patients with fibrosis stages < F2 have lower values of all noninvasive markers than patients with stages ≥F2. Patients with fibrosis stages ≥F2 but <F4 have lower values of APRI, Forns, FIB-4, GAPRI, and Hepascore than patients with stage F4. The values of noninvasive markers tested here differ in various stages of liver fibrosis. To our surprise, the patented marker, Hepascore, achieves a lower diagnostic value in alcoholics than simple markers involving only liver enzymes, platelet count, and cholesterol. The best marker of liver fibrosis in alcoholic patients seems to be the Forns index.http://dx.doi.org/10.1155/2019/3646975 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lech Chrostek Dagmara Przekop Ewa Gruszewska Monika Gudowska-Sawczuk Bogdan Cylwik |
spellingShingle |
Lech Chrostek Dagmara Przekop Ewa Gruszewska Monika Gudowska-Sawczuk Bogdan Cylwik Noninvasive Indirect Markers of Liver Fibrosis in Alcoholics BioMed Research International |
author_facet |
Lech Chrostek Dagmara Przekop Ewa Gruszewska Monika Gudowska-Sawczuk Bogdan Cylwik |
author_sort |
Lech Chrostek |
title |
Noninvasive Indirect Markers of Liver Fibrosis in Alcoholics |
title_short |
Noninvasive Indirect Markers of Liver Fibrosis in Alcoholics |
title_full |
Noninvasive Indirect Markers of Liver Fibrosis in Alcoholics |
title_fullStr |
Noninvasive Indirect Markers of Liver Fibrosis in Alcoholics |
title_full_unstemmed |
Noninvasive Indirect Markers of Liver Fibrosis in Alcoholics |
title_sort |
noninvasive indirect markers of liver fibrosis in alcoholics |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2019-01-01 |
description |
The aim of this study was to evaluate the diagnostic values of noninvasive indirect markers of liver fibrosis: APRI, GAPRI, Forns, FIB-4, Age-Platelet, and Hepascore in alcoholics. Blood samples were collected from a randomized group of 142 alcohol-dependent patients. The diagnosis of dependency was made according to the ICD-10 WHO criteria. The values of noninvasive markers were calculated with specific algorithms. The fibrosis stage was evaluated on the basis of FibroTest. The values of APRI, Forns, FIB-4, GAPRI, AP, and Hepascore differ between various stages of liver fibrosis. Patients with fibrosis stage F0 present lower values of APRI, Forns, FIB-4, GAPRI, and Hepascore in comparison to the patients with stages F1 and F0-F1. Patients with fibrosis stages < F2 have lower values of all noninvasive markers than patients with stages ≥F2. Patients with fibrosis stages ≥F2 but <F4 have lower values of APRI, Forns, FIB-4, GAPRI, and Hepascore than patients with stage F4. The values of noninvasive markers tested here differ in various stages of liver fibrosis. To our surprise, the patented marker, Hepascore, achieves a lower diagnostic value in alcoholics than simple markers involving only liver enzymes, platelet count, and cholesterol. The best marker of liver fibrosis in alcoholic patients seems to be the Forns index. |
url |
http://dx.doi.org/10.1155/2019/3646975 |
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