Recent Advances in Circadian Rhythms in Cardiovascular System
Growing evidence shows that intrinsic circadian clocks are tightly related to cardiovascular functions. The diurnal changes in blood pressure and heart rate are well known circadian rhythms. Endothelial function, platelet aggregation and thrombus formation exhibit circadian changes as well. The onse...
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doaj-1892578e7efb411b89799892949992862020-11-24T23:16:38ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122015-04-01610.3389/fphar.2015.00071134776Recent Advances in Circadian Rhythms in Cardiovascular SystemLihong eChen0Guangrui eYang1University of PennsylvaniaUniversity of PennsylvaniaGrowing evidence shows that intrinsic circadian clocks are tightly related to cardiovascular functions. The diurnal changes in blood pressure and heart rate are well known circadian rhythms. Endothelial function, platelet aggregation and thrombus formation exhibit circadian changes as well. The onset of many cardiovascular diseases (CVDs) or events, such as myocardial infarction, stroke, arrhythmia, and sudden cardiac death, also exhibits temporal trends. Furthermore, there is strong evidence from animal models and epidemiological studies showing that disruption of circadian rhythms is a significant risk factor for many CVDs, and the intervention of CVDs may have a time dependent effect. In this mini review, we summarized recent advances in our understanding of the relationship between circadian rhythm and cardiovascular physiology and diseases including blood pressure regulation and myocardial infarction.http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00071/fullBlood PressureCardiovascular DiseasesCircadian RhythmMyocardial InfarctionCircadian clock |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lihong eChen Guangrui eYang |
spellingShingle |
Lihong eChen Guangrui eYang Recent Advances in Circadian Rhythms in Cardiovascular System Frontiers in Pharmacology Blood Pressure Cardiovascular Diseases Circadian Rhythm Myocardial Infarction Circadian clock |
author_facet |
Lihong eChen Guangrui eYang |
author_sort |
Lihong eChen |
title |
Recent Advances in Circadian Rhythms in Cardiovascular System |
title_short |
Recent Advances in Circadian Rhythms in Cardiovascular System |
title_full |
Recent Advances in Circadian Rhythms in Cardiovascular System |
title_fullStr |
Recent Advances in Circadian Rhythms in Cardiovascular System |
title_full_unstemmed |
Recent Advances in Circadian Rhythms in Cardiovascular System |
title_sort |
recent advances in circadian rhythms in cardiovascular system |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pharmacology |
issn |
1663-9812 |
publishDate |
2015-04-01 |
description |
Growing evidence shows that intrinsic circadian clocks are tightly related to cardiovascular functions. The diurnal changes in blood pressure and heart rate are well known circadian rhythms. Endothelial function, platelet aggregation and thrombus formation exhibit circadian changes as well. The onset of many cardiovascular diseases (CVDs) or events, such as myocardial infarction, stroke, arrhythmia, and sudden cardiac death, also exhibits temporal trends. Furthermore, there is strong evidence from animal models and epidemiological studies showing that disruption of circadian rhythms is a significant risk factor for many CVDs, and the intervention of CVDs may have a time dependent effect. In this mini review, we summarized recent advances in our understanding of the relationship between circadian rhythm and cardiovascular physiology and diseases including blood pressure regulation and myocardial infarction. |
topic |
Blood Pressure Cardiovascular Diseases Circadian Rhythm Myocardial Infarction Circadian clock |
url |
http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00071/full |
work_keys_str_mv |
AT lihongechen recentadvancesincircadianrhythmsincardiovascularsystem AT guangruieyang recentadvancesincircadianrhythmsincardiovascularsystem |
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