Effect of LDL cholesterol, statins and presence of mutations on the prevalence of type 2 diabetes in heterozygous familial hypercholesterolemia
Abstract Patients with heterozygous familial hypercholesterolemia (HeFH) have been reported to be less vulnerable to type 2 diabetes mellitus (T2DM), although the mechanism is unknown. The aims of the present study were to assess the effects of low density lipoprotein (LDL) cholesterol concentration...
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doaj-189be5d1da01428a823d45e9a12a094c2020-12-08T00:48:25ZengNature Publishing GroupScientific Reports2045-23222017-07-01711810.1038/s41598-017-06101-6Effect of LDL cholesterol, statins and presence of mutations on the prevalence of type 2 diabetes in heterozygous familial hypercholesterolemiaElisenda Climent0Sofía Pérez-Calahorra1Victoria Marco-Benedí2Nuria Plana3Rosa Sánchez4Emilio Ros5Juan F. Ascaso6Jose Puzo7Fátima Almagro8Carlos Lahoz9Fernando Civeira10Juan Pedro-Botet11Lipid and Vascular Unit, Department of Endocrinology and Nutrition, Hospital del Mar, Universitat Autònoma de BarcelonaLipid Unit. Hospital Universitario Miguel Servet, IIS Aragón, Universidad de ZaragozaLipid Unit. Hospital Universitario Miguel Servet, IIS Aragón, Universidad de ZaragozaUnitat de Medicina Vascular i Metabolisme, Hospital Universitari Sant Joan, Institut d´Investigació Sanitaria Pere Virgili (IISPV)Lipid Unit, Servicio de Endocrinología y Nutrición, Hospital Universitario Insular de Gran Canarias, Instituto Universitario de Investigaciones Biomédicas y Sanitarias de la Universidad de Las Palmas de Gran CanariasLipid Clinic, Endocrinology and Nutrition Service, Institut d’Investigacions Biomèdiques August Pi Sunyer, Hospital Clínic, Barcelona and CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII)Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Universitat de ValenciaLipid Unit. Hospital San JorgeLipid Unit, Hospital DonostiaAtherosclerosis Unit, Internal Medicine Department, Hospital Carlos IIILipid Unit. Hospital Universitario Miguel Servet, IIS Aragón, Universidad de ZaragozaLipid and Vascular Unit, Department of Endocrinology and Nutrition, Hospital del Mar, Universitat Autònoma de BarcelonaAbstract Patients with heterozygous familial hypercholesterolemia (HeFH) have been reported to be less vulnerable to type 2 diabetes mellitus (T2DM), although the mechanism is unknown. The aims of the present study were to assess the effects of low density lipoprotein (LDL) cholesterol concentration and the presence of FH-causing mutations on T2DM prevalence in HeFH. Data were collected from the Dyslipidemia Registry of the Spanish Arteriosclerosis Society. Inclusion criteria were definite or probable HeFH in patients aged ≥18 years. T2DM prevalence in HeFH patients was compared with data of the general population. 1732 patients were included. The prevalence of T2DM was lower in patients with HeFH compared with the general population (5.94% vs 9.44%; OR: 0.606, 95% CI 0.486–0.755, p < 0.001). Risk factors for developing T2DM were male sex, age, body mass index, hypertension, baseline triglyceride levels and years on statin therapy. The prevalence of T2DM in HeFH patients was 40% lower than that observed in the general population. Gene mutations and LDL cholesterol concentrations were not risk factors associated with the prevalence of T2DM in patients with HeFH. The prevalence of T2DM in patients with HeFH was 40% lower than in the general population matched for age and sex.https://doi.org/10.1038/s41598-017-06101-6 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elisenda Climent Sofía Pérez-Calahorra Victoria Marco-Benedí Nuria Plana Rosa Sánchez Emilio Ros Juan F. Ascaso Jose Puzo Fátima Almagro Carlos Lahoz Fernando Civeira Juan Pedro-Botet |
spellingShingle |
Elisenda Climent Sofía Pérez-Calahorra Victoria Marco-Benedí Nuria Plana Rosa Sánchez Emilio Ros Juan F. Ascaso Jose Puzo Fátima Almagro Carlos Lahoz Fernando Civeira Juan Pedro-Botet Effect of LDL cholesterol, statins and presence of mutations on the prevalence of type 2 diabetes in heterozygous familial hypercholesterolemia Scientific Reports |
author_facet |
Elisenda Climent Sofía Pérez-Calahorra Victoria Marco-Benedí Nuria Plana Rosa Sánchez Emilio Ros Juan F. Ascaso Jose Puzo Fátima Almagro Carlos Lahoz Fernando Civeira Juan Pedro-Botet |
author_sort |
Elisenda Climent |
title |
Effect of LDL cholesterol, statins and presence of mutations on the prevalence of type 2 diabetes in heterozygous familial hypercholesterolemia |
title_short |
Effect of LDL cholesterol, statins and presence of mutations on the prevalence of type 2 diabetes in heterozygous familial hypercholesterolemia |
title_full |
Effect of LDL cholesterol, statins and presence of mutations on the prevalence of type 2 diabetes in heterozygous familial hypercholesterolemia |
title_fullStr |
Effect of LDL cholesterol, statins and presence of mutations on the prevalence of type 2 diabetes in heterozygous familial hypercholesterolemia |
title_full_unstemmed |
Effect of LDL cholesterol, statins and presence of mutations on the prevalence of type 2 diabetes in heterozygous familial hypercholesterolemia |
title_sort |
effect of ldl cholesterol, statins and presence of mutations on the prevalence of type 2 diabetes in heterozygous familial hypercholesterolemia |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2017-07-01 |
description |
Abstract Patients with heterozygous familial hypercholesterolemia (HeFH) have been reported to be less vulnerable to type 2 diabetes mellitus (T2DM), although the mechanism is unknown. The aims of the present study were to assess the effects of low density lipoprotein (LDL) cholesterol concentration and the presence of FH-causing mutations on T2DM prevalence in HeFH. Data were collected from the Dyslipidemia Registry of the Spanish Arteriosclerosis Society. Inclusion criteria were definite or probable HeFH in patients aged ≥18 years. T2DM prevalence in HeFH patients was compared with data of the general population. 1732 patients were included. The prevalence of T2DM was lower in patients with HeFH compared with the general population (5.94% vs 9.44%; OR: 0.606, 95% CI 0.486–0.755, p < 0.001). Risk factors for developing T2DM were male sex, age, body mass index, hypertension, baseline triglyceride levels and years on statin therapy. The prevalence of T2DM in HeFH patients was 40% lower than that observed in the general population. Gene mutations and LDL cholesterol concentrations were not risk factors associated with the prevalence of T2DM in patients with HeFH. The prevalence of T2DM in patients with HeFH was 40% lower than in the general population matched for age and sex. |
url |
https://doi.org/10.1038/s41598-017-06101-6 |
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