Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic
Chronic exposure to arsenic (As), whether directly through the consumption of contaminated drinking water or indirectly through the daily intake of As-contaminated food, is a health threat for more than 150 million people worldwide. Epidemiological studies found an association between chronic consum...
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doaj-189e2e3a03d242028fdf3a262eec9f682020-11-24T21:36:15ZengHindawi LimitedBioMed Research International2314-61332314-61412019-01-01201910.1155/2019/49780184978018Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to ArsenicCesar Rivas-Santiago0Irma González-Curiel1Sergio Zarazua2Michael Murgu3Alonso Ruiz Cardona4Blanca Lazalde5Edgar E. Lara-Ramírez6Edgar Vázquez7Julio Enrique Castañeda-Delgado8Bruno Rivas-Santiago9Jesús Adrián Lopez10Alberto R. Cervantes-Villagrana11Yamilé López-Hernández12CONACyT, Unidad Académica de Ciencias Biológicas, Universidad Autónoma de Zacatecas, Zacatecas, MexicoMaestría en Ciencia y Tecnología Química, Unidad Académica de Ciencias Químicas, Universidad Autónoma de Zacatecas, Zacatecas, MexicoLaboratorio de Neurotoxicología, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, San Luis Potosí, MexicoWaters Technologies of Brazil, Barueri, BrazilLaboratorio de Neurotoxicología, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, San Luis Potosí, MexicoMaestría en Ciencia y Tecnología Química, Unidad Académica de Ciencias Químicas, Universidad Autónoma de Zacatecas, Zacatecas, MexicoUnidad de Investigación Biomédica de Zacatecas, Instituto Mexicano de Seguro Social, Zacatecas, MexicoWaters Corporation, Mexico City, MexicoCatedrático-CONACYT, Unidad de Investigación Biomédica de Zacatecas-IMSS. Zacatecas, Zacatecas, MexicoUnidad de Investigación Biomédica de Zacatecas, Instituto Mexicano de Seguro Social, Zacatecas, MexicoLaboratorio de microRNAs, Unidad Académica de Ciencias Biológicas, Universidad Autónoma de Zacatecas, Zacatecas, MexicoMaestría en Ciencia y Tecnología Química, Unidad Académica de Ciencias Químicas, Universidad Autónoma de Zacatecas, Zacatecas, MexicoCONACyT, Unidad Académica de Ciencias Biológicas, Universidad Autónoma de Zacatecas, Zacatecas, MexicoChronic exposure to arsenic (As), whether directly through the consumption of contaminated drinking water or indirectly through the daily intake of As-contaminated food, is a health threat for more than 150 million people worldwide. Epidemiological studies found an association between chronic consumption of As and several pathologies, the most common being cancer-related disorders. However, As consumption has also been associated with metabolic disorders that could lead to diverse pathologies, such as type 2 diabetes mellitus, nonalcoholic fatty liver disease, and obesity. Here, we used ultra-performance liquid chromatography (UPLC) coupled to electrospray ionization/quadrupole time-of-flight mass spectrometry (ESI-QToF) to assess the effect of chronic intergenerational As exposure on the lipid metabolism profiles of serum from 4-month-old Wistar rats exposed to As prenatally and also during early life in drinking water (3 ppm). Significant differences in the levels of certain identified lysophospholipids, phosphatidylcholines, and triglycerides were found between the exposed rats and the control groups, as well as between the sexes. Significantly increased lipid oxidation determined by the malondialdehyde (MDA) method was found in exposed rats compared with controls. Chronic intergenerational As exposure alters the rat lipidome, increases lipid oxidation, and dysregulates metabolic pathways, the factors associated with the chronic inflammation present in different diseases associated with chronic exposure to As (i.e., keratosis, Bowen’s disease, and kidney, liver, bladder, and lung cancer).http://dx.doi.org/10.1155/2019/4978018 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cesar Rivas-Santiago Irma González-Curiel Sergio Zarazua Michael Murgu Alonso Ruiz Cardona Blanca Lazalde Edgar E. Lara-Ramírez Edgar Vázquez Julio Enrique Castañeda-Delgado Bruno Rivas-Santiago Jesús Adrián Lopez Alberto R. Cervantes-Villagrana Yamilé López-Hernández |
spellingShingle |
Cesar Rivas-Santiago Irma González-Curiel Sergio Zarazua Michael Murgu Alonso Ruiz Cardona Blanca Lazalde Edgar E. Lara-Ramírez Edgar Vázquez Julio Enrique Castañeda-Delgado Bruno Rivas-Santiago Jesús Adrián Lopez Alberto R. Cervantes-Villagrana Yamilé López-Hernández Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic BioMed Research International |
author_facet |
Cesar Rivas-Santiago Irma González-Curiel Sergio Zarazua Michael Murgu Alonso Ruiz Cardona Blanca Lazalde Edgar E. Lara-Ramírez Edgar Vázquez Julio Enrique Castañeda-Delgado Bruno Rivas-Santiago Jesús Adrián Lopez Alberto R. Cervantes-Villagrana Yamilé López-Hernández |
author_sort |
Cesar Rivas-Santiago |
title |
Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic |
title_short |
Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic |
title_full |
Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic |
title_fullStr |
Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic |
title_full_unstemmed |
Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic |
title_sort |
lipid metabolism alterations in a rat model of chronic and intergenerational exposure to arsenic |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2019-01-01 |
description |
Chronic exposure to arsenic (As), whether directly through the consumption of contaminated drinking water or indirectly through the daily intake of As-contaminated food, is a health threat for more than 150 million people worldwide. Epidemiological studies found an association between chronic consumption of As and several pathologies, the most common being cancer-related disorders. However, As consumption has also been associated with metabolic disorders that could lead to diverse pathologies, such as type 2 diabetes mellitus, nonalcoholic fatty liver disease, and obesity. Here, we used ultra-performance liquid chromatography (UPLC) coupled to electrospray ionization/quadrupole time-of-flight mass spectrometry (ESI-QToF) to assess the effect of chronic intergenerational As exposure on the lipid metabolism profiles of serum from 4-month-old Wistar rats exposed to As prenatally and also during early life in drinking water (3 ppm). Significant differences in the levels of certain identified lysophospholipids, phosphatidylcholines, and triglycerides were found between the exposed rats and the control groups, as well as between the sexes. Significantly increased lipid oxidation determined by the malondialdehyde (MDA) method was found in exposed rats compared with controls. Chronic intergenerational As exposure alters the rat lipidome, increases lipid oxidation, and dysregulates metabolic pathways, the factors associated with the chronic inflammation present in different diseases associated with chronic exposure to As (i.e., keratosis, Bowen’s disease, and kidney, liver, bladder, and lung cancer). |
url |
http://dx.doi.org/10.1155/2019/4978018 |
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