Head-to-Head Comparison of Different Software Solutions for AVC Quantification Using Contrast-Enhanced MDCT
Aortic valve calcification (AVC) in aortic stenosis patients has diagnostic and prognostic implications. Little is known about the interchangeability of AVC obtained from different multidetector computed tomography (MDCT) software solutions. Contrast-enhanced MDCT data sets of 50 randomly selected a...
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doaj-18b4461b3d1c41cdaf6dae3cf0f3017a2021-09-09T13:49:54ZengMDPI AGJournal of Clinical Medicine2077-03832021-09-01103970397010.3390/jcm10173970Head-to-Head Comparison of Different Software Solutions for AVC Quantification Using Contrast-Enhanced MDCTRuben Evertz0Sebastian Hub1Sören J. Backhaus2Torben Lange3Karl Toischer4Johannes T. Kowallick5Gerd Hasenfuß6Andreas Schuster7Department of Cardiology and Pneumology, University Medical Center Goettingen (UMG), 37075 Goettingen, GermanyDepartment of Cardiology and Pneumology, University Medical Center Goettingen (UMG), 37075 Goettingen, GermanyDepartment of Cardiology and Pneumology, University Medical Center Goettingen (UMG), 37075 Goettingen, GermanyDepartment of Cardiology and Pneumology, University Medical Center Goettingen (UMG), 37075 Goettingen, GermanyDepartment of Cardiology and Pneumology, University Medical Center Goettingen (UMG), 37075 Goettingen, GermanyGerman Center for Cardiovascular Research (DZHK), 37099 Göttingen, GermanyDepartment of Cardiology and Pneumology, University Medical Center Goettingen (UMG), 37075 Goettingen, GermanyDepartment of Cardiology and Pneumology, University Medical Center Goettingen (UMG), 37075 Goettingen, GermanyAortic valve calcification (AVC) in aortic stenosis patients has diagnostic and prognostic implications. Little is known about the interchangeability of AVC obtained from different multidetector computed tomography (MDCT) software solutions. Contrast-enhanced MDCT data sets of 50 randomly selected aortic stenosis patients were analysed using three different software vendors (3Mensio, CVI42, Syngo.Via). A subset of 10 patients were analysed twice for the estimation of intra-observer variability. Intra- and inter-observer variability were determined using the ICC reliability method, Bland-Altman analysis and coefficients of variation. No differences were revealed between the software solutions in the AVC calculations (3Mensio 941 ± 623, Syngo.Via 948 mm<sup>3</sup> ± 655, CVI42 941 ± 637; <i>p</i> = 0.455). The best inter-vendor agreement was found between the CVI42 and the Syngo.Via (ICC 0.997 (CI 0.995–0.998)), followed by the 3Mensio and the CVI42 (ICC 0.996 (CI 0.922–0.998)), and the 3Mensio and the Syngo.Via (ICC 0.992 (CI 0.986–0.995)). There was excellent intra- (3Mensio: ICC 0.999 (0.995–1.000); CVI42: ICC 1.000 (0.999–1.000); Syngo.Via: ICC 0.998 (0.993–1.000)) and inter-observer variability (3Mensio: ICC 1.000 (0.999–1.000); CVI42: ICC 1.000 (1.000–1.000); Syngo.Via: ICC 0.996 (0.985–0.999)) for all software types. Contrast-enhanced MDCT-derived AVC scores are interchangeable between and reproducible within different commercially available software solutions. This is important since sufficient reproducibility, interchangeability and valid results represent prerequisites for accurate TAVR planning and its widespread clinical use.https://www.mdpi.com/2077-0383/10/17/3970aortic stenosisaortic valve calcificationcontrast-enhanced MDCTinter-vendor variability |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ruben Evertz Sebastian Hub Sören J. Backhaus Torben Lange Karl Toischer Johannes T. Kowallick Gerd Hasenfuß Andreas Schuster |
spellingShingle |
Ruben Evertz Sebastian Hub Sören J. Backhaus Torben Lange Karl Toischer Johannes T. Kowallick Gerd Hasenfuß Andreas Schuster Head-to-Head Comparison of Different Software Solutions for AVC Quantification Using Contrast-Enhanced MDCT Journal of Clinical Medicine aortic stenosis aortic valve calcification contrast-enhanced MDCT inter-vendor variability |
author_facet |
Ruben Evertz Sebastian Hub Sören J. Backhaus Torben Lange Karl Toischer Johannes T. Kowallick Gerd Hasenfuß Andreas Schuster |
author_sort |
Ruben Evertz |
title |
Head-to-Head Comparison of Different Software Solutions for AVC Quantification Using Contrast-Enhanced MDCT |
title_short |
Head-to-Head Comparison of Different Software Solutions for AVC Quantification Using Contrast-Enhanced MDCT |
title_full |
Head-to-Head Comparison of Different Software Solutions for AVC Quantification Using Contrast-Enhanced MDCT |
title_fullStr |
Head-to-Head Comparison of Different Software Solutions for AVC Quantification Using Contrast-Enhanced MDCT |
title_full_unstemmed |
Head-to-Head Comparison of Different Software Solutions for AVC Quantification Using Contrast-Enhanced MDCT |
title_sort |
head-to-head comparison of different software solutions for avc quantification using contrast-enhanced mdct |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2021-09-01 |
description |
Aortic valve calcification (AVC) in aortic stenosis patients has diagnostic and prognostic implications. Little is known about the interchangeability of AVC obtained from different multidetector computed tomography (MDCT) software solutions. Contrast-enhanced MDCT data sets of 50 randomly selected aortic stenosis patients were analysed using three different software vendors (3Mensio, CVI42, Syngo.Via). A subset of 10 patients were analysed twice for the estimation of intra-observer variability. Intra- and inter-observer variability were determined using the ICC reliability method, Bland-Altman analysis and coefficients of variation. No differences were revealed between the software solutions in the AVC calculations (3Mensio 941 ± 623, Syngo.Via 948 mm<sup>3</sup> ± 655, CVI42 941 ± 637; <i>p</i> = 0.455). The best inter-vendor agreement was found between the CVI42 and the Syngo.Via (ICC 0.997 (CI 0.995–0.998)), followed by the 3Mensio and the CVI42 (ICC 0.996 (CI 0.922–0.998)), and the 3Mensio and the Syngo.Via (ICC 0.992 (CI 0.986–0.995)). There was excellent intra- (3Mensio: ICC 0.999 (0.995–1.000); CVI42: ICC 1.000 (0.999–1.000); Syngo.Via: ICC 0.998 (0.993–1.000)) and inter-observer variability (3Mensio: ICC 1.000 (0.999–1.000); CVI42: ICC 1.000 (1.000–1.000); Syngo.Via: ICC 0.996 (0.985–0.999)) for all software types. Contrast-enhanced MDCT-derived AVC scores are interchangeable between and reproducible within different commercially available software solutions. This is important since sufficient reproducibility, interchangeability and valid results represent prerequisites for accurate TAVR planning and its widespread clinical use. |
topic |
aortic stenosis aortic valve calcification contrast-enhanced MDCT inter-vendor variability |
url |
https://www.mdpi.com/2077-0383/10/17/3970 |
work_keys_str_mv |
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