Heterochromatin protein 1a functions for piRNA biogenesis predominantly from pericentric and telomeric regions in Drosophila

Heterochromatin protein 1a functions for piRNA biogenesis predominantly from pericentric and telomeric regions in Drosophila

Heterochromatin protein 1a (HP1a) is thought to function downstream of transposon repression in the Drosophila female germline. Here the authors show that HP1a also functions upstream of piRNA processing by repressing splicing of piRNA precursors, predominantly at telomeric and centromeric regions.

Bibliographic Details
Main Authors: Ryan Yee Wei Teo, Amit Anand, Vishweshwaren Sridhar, Katsutomo Okamura, Toshie Kai
Format: Article
Language:English
Published: Nature Publishing Group 2018-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03908-3
id doaj-18b6e29e690a4b95a059b73a2718afe4
record_format Article
spelling doaj-18b6e29e690a4b95a059b73a2718afe42021-05-11T09:58:46ZengNature Publishing GroupNature Communications2041-17232018-05-019111210.1038/s41467-018-03908-3Heterochromatin protein 1a functions for piRNA biogenesis predominantly from pericentric and telomeric regions in DrosophilaRyan Yee Wei Teo0Amit Anand1Vishweshwaren Sridhar2Katsutomo Okamura3Toshie Kai4Temasek Life Sciences Laboratory, 1 Research Link, National University of SingaporeTemasek Life Sciences Laboratory, 1 Research Link, National University of SingaporeTemasek Life Sciences Laboratory, 1 Research Link, National University of SingaporeTemasek Life Sciences Laboratory, 1 Research Link, National University of SingaporeGraduate School of Frontier Biosciences, Osaka UniversityHeterochromatin protein 1a (HP1a) is thought to function downstream of transposon repression in the Drosophila female germline. Here the authors show that HP1a also functions upstream of piRNA processing by repressing splicing of piRNA precursors, predominantly at telomeric and centromeric regions.https://doi.org/10.1038/s41467-018-03908-3
collection DOAJ
language English
format Article
sources DOAJ
author Ryan Yee Wei Teo
Amit Anand
Vishweshwaren Sridhar
Katsutomo Okamura
Toshie Kai
spellingShingle Ryan Yee Wei Teo
Amit Anand
Vishweshwaren Sridhar
Katsutomo Okamura
Toshie Kai
Heterochromatin protein 1a functions for piRNA biogenesis predominantly from pericentric and telomeric regions in Drosophila
Nature Communications
author_facet Ryan Yee Wei Teo
Amit Anand
Vishweshwaren Sridhar
Katsutomo Okamura
Toshie Kai
author_sort Ryan Yee Wei Teo
title Heterochromatin protein 1a functions for piRNA biogenesis predominantly from pericentric and telomeric regions in Drosophila
title_short Heterochromatin protein 1a functions for piRNA biogenesis predominantly from pericentric and telomeric regions in Drosophila
title_full Heterochromatin protein 1a functions for piRNA biogenesis predominantly from pericentric and telomeric regions in Drosophila
title_fullStr Heterochromatin protein 1a functions for piRNA biogenesis predominantly from pericentric and telomeric regions in Drosophila
title_full_unstemmed Heterochromatin protein 1a functions for piRNA biogenesis predominantly from pericentric and telomeric regions in Drosophila
title_sort heterochromatin protein 1a functions for pirna biogenesis predominantly from pericentric and telomeric regions in drosophila
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-05-01
description Heterochromatin protein 1a (HP1a) is thought to function downstream of transposon repression in the Drosophila female germline. Here the authors show that HP1a also functions upstream of piRNA processing by repressing splicing of piRNA precursors, predominantly at telomeric and centromeric regions.
url https://doi.org/10.1038/s41467-018-03908-3
work_keys_str_mv AT ryanyeeweiteo heterochromatinprotein1afunctionsforpirnabiogenesispredominantlyfrompericentricandtelomericregionsindrosophila
AT amitanand heterochromatinprotein1afunctionsforpirnabiogenesispredominantlyfrompericentricandtelomericregionsindrosophila
AT vishweshwarensridhar heterochromatinprotein1afunctionsforpirnabiogenesispredominantlyfrompericentricandtelomericregionsindrosophila
AT katsutomookamura heterochromatinprotein1afunctionsforpirnabiogenesispredominantlyfrompericentricandtelomericregionsindrosophila
AT toshiekai heterochromatinprotein1afunctionsforpirnabiogenesispredominantlyfrompericentricandtelomericregionsindrosophila
_version_ 1721448910944206848

Similar Items