Schizotrypanids: the occurence of dermatitis in immunodeficiency animals infected with Trypanosoma cruzi

• Main Authors: Sylvio Celso Gonçalves da Costa, Kátia da Silva Calabrese
• Format: Article
• Language: English
• Published: Instituto Oswaldo Cruz, Ministério da Saúde 1992-01-01
• Series: Memórias do Instituto Oswaldo Cruz.
• Subjects: Trypanosoma cruzi; dermatitis; immunodeficience; schizotrypanids; nude mice
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000500015

Congenitally athymic nude Balb/c (nu/nu) and their phenothypically normal adult and neonate littermates (nu/+), the C3H/HeN as well, were intraperitoneally infected with two strains (Y or CL) of Trypanossoma cruzi. The nude mice and the neonates developed a severe parasitaemia, the susceptible C3H/HeN also presented high level and adult Balb/c mice presented parasitaemia similar to that observed in outbred mice. Erythematous skin lesions were observed initially in infected athymic nude and neonates, being charactherized by nests of amastigotes in the dermis; in C3H/HeN infected mice no nest of parasite was observed but a low-grade inflammatory reaction was seen. In adult Balb/c or OF1 outbred mice nest was found but discreet inflammatory reaction was observed in severe infections.