Micro-RNAs in the regulation of immune response against SARS CoV-2 and other viral infections
Background: Micro-RNAs (miRNAS) are non-coding, small RNAs that have essential roles in different biological processes through silencing genes, they consist of 18–24 nucleotide length RNA molecules. Recently, miRNAs have been viewed as important modulators of viral infections they can function as su...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-05-01
|
Series: | Journal of Advanced Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123220302393 |
id |
doaj-18c900a833d045df95cd69f9dc3fff36 |
---|---|
record_format |
Article |
spelling |
doaj-18c900a833d045df95cd69f9dc3fff362021-05-18T04:10:48ZengElsevierJournal of Advanced Research2090-12322021-05-0130133145Micro-RNAs in the regulation of immune response against SARS CoV-2 and other viral infectionsTareq Abu-Izneid0Noora AlHajri1Abdallah Mohammad Ibrahim2Md. Noushad Javed3Khairi Mustafa Salem4Faheem Hyder Pottoo5Mohammad Amjad Kamal6Pharmaceutical Sciences, College of Pharmacy, Al Ain University, Al Ain, Abu Dhabi, United Arab EmiratesDepartment of Epidemiology and Population Health, College of Medicine, Khalifa University, United Arab EmiratesFundamentals of Nursing Department, College of Nursing, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi ArabiaDepartment of Pharmaceutics, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, New-Delhi, IndiaPharmaceutical Sciences, College of Pharmacy, Al Ain University, Al Ain, Abu Dhabi, United Arab EmiratesDepartment of Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi ArabiaWest China School of Nursing/Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589, Saudi Arabia; Enzymoics, Novel Global Community Educational Foundation, 7 Peterlee Place, Hebersham, NSW 2770, Australia; Corresponding author.Background: Micro-RNAs (miRNAS) are non-coding, small RNAs that have essential roles in different biological processes through silencing genes, they consist of 18–24 nucleotide length RNA molecules. Recently, miRNAs have been viewed as important modulators of viral infections they can function as suppressors of gene expression by targeting cellular or viral RNAs during infection. Aim of review: We describe the biological roles and effects of miRNAs on SARS-CoV-2 life-cycle and pathogenicity, and we discuss the modulation of the immune system with micro-RNAs which would serve as a new foundation for the treatment of SARS-CoV-2 and other viral infections. Key scientific concepts of review: miRNAs are the key players that regulate the expression of the gene in the post-transcriptional phase and have important effects on viral infections, thus are potential targets in the development of novel therapeutics for the treatment of viral infections. Besides, micro-RNAs (miRNAs) modulation of immune-pathogenesis responses to viral infection is one of the most-known indirect effects, which leads to suppressing of the interferon (IFN-α/β) signalling cascade or upregulation of the IFN-α/β production another IFN-stimulated gene (ISGs) that inhibit replication of the virus. These virus-mediated alterations in miRNA levels lead to an environment that might either enhance or inhibit virus replication.http://www.sciencedirect.com/science/article/pii/S2090123220302393miRNAsCOVID-19SARS-CoV-2Viral infectionsBiomarkersImmunotherapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tareq Abu-Izneid Noora AlHajri Abdallah Mohammad Ibrahim Md. Noushad Javed Khairi Mustafa Salem Faheem Hyder Pottoo Mohammad Amjad Kamal |
spellingShingle |
Tareq Abu-Izneid Noora AlHajri Abdallah Mohammad Ibrahim Md. Noushad Javed Khairi Mustafa Salem Faheem Hyder Pottoo Mohammad Amjad Kamal Micro-RNAs in the regulation of immune response against SARS CoV-2 and other viral infections Journal of Advanced Research miRNAs COVID-19 SARS-CoV-2 Viral infections Biomarkers Immunotherapy |
author_facet |
Tareq Abu-Izneid Noora AlHajri Abdallah Mohammad Ibrahim Md. Noushad Javed Khairi Mustafa Salem Faheem Hyder Pottoo Mohammad Amjad Kamal |
author_sort |
Tareq Abu-Izneid |
title |
Micro-RNAs in the regulation of immune response against SARS CoV-2 and other viral infections |
title_short |
Micro-RNAs in the regulation of immune response against SARS CoV-2 and other viral infections |
title_full |
Micro-RNAs in the regulation of immune response against SARS CoV-2 and other viral infections |
title_fullStr |
Micro-RNAs in the regulation of immune response against SARS CoV-2 and other viral infections |
title_full_unstemmed |
Micro-RNAs in the regulation of immune response against SARS CoV-2 and other viral infections |
title_sort |
micro-rnas in the regulation of immune response against sars cov-2 and other viral infections |
publisher |
Elsevier |
series |
Journal of Advanced Research |
issn |
2090-1232 |
publishDate |
2021-05-01 |
description |
Background: Micro-RNAs (miRNAS) are non-coding, small RNAs that have essential roles in different biological processes through silencing genes, they consist of 18–24 nucleotide length RNA molecules. Recently, miRNAs have been viewed as important modulators of viral infections they can function as suppressors of gene expression by targeting cellular or viral RNAs during infection. Aim of review: We describe the biological roles and effects of miRNAs on SARS-CoV-2 life-cycle and pathogenicity, and we discuss the modulation of the immune system with micro-RNAs which would serve as a new foundation for the treatment of SARS-CoV-2 and other viral infections. Key scientific concepts of review: miRNAs are the key players that regulate the expression of the gene in the post-transcriptional phase and have important effects on viral infections, thus are potential targets in the development of novel therapeutics for the treatment of viral infections. Besides, micro-RNAs (miRNAs) modulation of immune-pathogenesis responses to viral infection is one of the most-known indirect effects, which leads to suppressing of the interferon (IFN-α/β) signalling cascade or upregulation of the IFN-α/β production another IFN-stimulated gene (ISGs) that inhibit replication of the virus. These virus-mediated alterations in miRNA levels lead to an environment that might either enhance or inhibit virus replication. |
topic |
miRNAs COVID-19 SARS-CoV-2 Viral infections Biomarkers Immunotherapy |
url |
http://www.sciencedirect.com/science/article/pii/S2090123220302393 |
work_keys_str_mv |
AT tareqabuizneid micrornasintheregulationofimmuneresponseagainstsarscov2andotherviralinfections AT nooraalhajri micrornasintheregulationofimmuneresponseagainstsarscov2andotherviralinfections AT abdallahmohammadibrahim micrornasintheregulationofimmuneresponseagainstsarscov2andotherviralinfections AT mdnoushadjaved micrornasintheregulationofimmuneresponseagainstsarscov2andotherviralinfections AT khairimustafasalem micrornasintheregulationofimmuneresponseagainstsarscov2andotherviralinfections AT faheemhyderpottoo micrornasintheregulationofimmuneresponseagainstsarscov2andotherviralinfections AT mohammadamjadkamal micrornasintheregulationofimmuneresponseagainstsarscov2andotherviralinfections |
_version_ |
1721437857759887360 |