Modulation of Hippocampal Neural Plasticity by Glucose-Related Signaling
Hormones and peptides involved in glucose homeostasis are emerging as important modulators of neural plasticity. In this regard, increasing evidence shows that molecules such as insulin, insulin-like growth factor-I, glucagon-like peptide-1, and ghrelin impact on the function of the hippocampus, whi...
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Series: | Neural Plasticity |
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doaj-18cb8ad8a3ec4844b755da5aa47451d32020-11-24T22:02:19ZengHindawi LimitedNeural Plasticity2090-59041687-54432015-01-01201510.1155/2015/657928657928Modulation of Hippocampal Neural Plasticity by Glucose-Related SignalingMarco Mainardi0Salvatore Fusco1Claudio Grassi2Institute of Human Physiology, Medical School, Università Cattolica, Largo Francesco Vito 1, 00168 Rome, ItalyInstitute of Human Physiology, Medical School, Università Cattolica, Largo Francesco Vito 1, 00168 Rome, ItalyInstitute of Human Physiology, Medical School, Università Cattolica, Largo Francesco Vito 1, 00168 Rome, ItalyHormones and peptides involved in glucose homeostasis are emerging as important modulators of neural plasticity. In this regard, increasing evidence shows that molecules such as insulin, insulin-like growth factor-I, glucagon-like peptide-1, and ghrelin impact on the function of the hippocampus, which is a key area for learning and memory. Indeed, all these factors affect fundamental hippocampal properties including synaptic plasticity (i.e., synapse potentiation and depression), structural plasticity (i.e., dynamics of dendritic spines), and adult neurogenesis, thus leading to modifications in cognitive performance. Here, we review the main mechanisms underlying the effects of glucose metabolism on hippocampal physiology. In particular, we discuss the role of these signals in the modulation of cognitive functions and their potential implications in dysmetabolism-related cognitive decline.http://dx.doi.org/10.1155/2015/657928 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marco Mainardi Salvatore Fusco Claudio Grassi |
spellingShingle |
Marco Mainardi Salvatore Fusco Claudio Grassi Modulation of Hippocampal Neural Plasticity by Glucose-Related Signaling Neural Plasticity |
author_facet |
Marco Mainardi Salvatore Fusco Claudio Grassi |
author_sort |
Marco Mainardi |
title |
Modulation of Hippocampal Neural Plasticity by Glucose-Related Signaling |
title_short |
Modulation of Hippocampal Neural Plasticity by Glucose-Related Signaling |
title_full |
Modulation of Hippocampal Neural Plasticity by Glucose-Related Signaling |
title_fullStr |
Modulation of Hippocampal Neural Plasticity by Glucose-Related Signaling |
title_full_unstemmed |
Modulation of Hippocampal Neural Plasticity by Glucose-Related Signaling |
title_sort |
modulation of hippocampal neural plasticity by glucose-related signaling |
publisher |
Hindawi Limited |
series |
Neural Plasticity |
issn |
2090-5904 1687-5443 |
publishDate |
2015-01-01 |
description |
Hormones and peptides involved in glucose homeostasis are emerging as important modulators of neural plasticity. In this regard, increasing evidence shows that molecules such as insulin, insulin-like growth factor-I, glucagon-like peptide-1, and ghrelin impact on the function of the hippocampus, which is a key area for learning and memory. Indeed, all these factors affect fundamental hippocampal properties including synaptic plasticity (i.e., synapse potentiation and depression), structural plasticity (i.e., dynamics of dendritic spines), and adult neurogenesis, thus leading to modifications in cognitive performance. Here, we review the main mechanisms underlying the effects of glucose metabolism on hippocampal physiology. In particular, we discuss the role of these signals in the modulation of cognitive functions and their potential implications in dysmetabolism-related cognitive decline. |
url |
http://dx.doi.org/10.1155/2015/657928 |
work_keys_str_mv |
AT marcomainardi modulationofhippocampalneuralplasticitybyglucoserelatedsignaling AT salvatorefusco modulationofhippocampalneuralplasticitybyglucoserelatedsignaling AT claudiograssi modulationofhippocampalneuralplasticitybyglucoserelatedsignaling |
_version_ |
1725836472452382720 |