Spiny and Non-spiny Parvalbumin-Positive Hippocampal Interneurons Show Different Plastic Properties
Summary: Dendritic spines control synaptic transmission and plasticity by augmenting post-synaptic potentials and providing biochemical compartmentalization. In principal cells, spines cover the dendritic tree at high densities, receive the overwhelming majority of excitatory inputs, and undergo exp...
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doaj-18d636f44d954499aa605f3c9ac6901f2020-11-25T02:07:44ZengElsevierCell Reports2211-12472019-06-01271337253732.e5Spiny and Non-spiny Parvalbumin-Positive Hippocampal Interneurons Show Different Plastic PropertiesAngelica Foggetti0Gilda Baccini1Philipp Arnold2Thomas Schiffelholz3Peer Wulff4Institute of Physiology, Christian-Albrechts-University Kiel, 24098 Kiel, Germany; Corresponding authorInstitute of Physiology, Christian-Albrechts-University Kiel, 24098 Kiel, GermanyAnatomical Institute, Christian-Albrechts-University Kiel, 24118 Kiel, GermanyDepartment of Psychiatry and Psychotherapy, Christian-Albrechts-University Kiel, 24105 Kiel, GermanyInstitute of Physiology, Christian-Albrechts-University Kiel, 24098 Kiel, Germany; Corresponding authorSummary: Dendritic spines control synaptic transmission and plasticity by augmenting post-synaptic potentials and providing biochemical compartmentalization. In principal cells, spines cover the dendritic tree at high densities, receive the overwhelming majority of excitatory inputs, and undergo experience-dependent structural re-organization. Although GABAergic interneurons have long been considered to be devoid of spines, a number of studies have reported the sparse existence of spines in interneurons. However, little is known about their organization or function at the cellular and network level. Here, we show that a subset of hippocampal parvalbumin-positive interneurons forms numerous dendritic spines with highly variable densities and input-selective organization. These spines form in areas with reduced perineuronal net sheathing, predispose for plastic changes in protein expression, and show input-specific re-organization after behavioral experience. : Dendritic spines on excitatory principal cells are critical sites of learning-induced plasticity. Foggetti et al. report that a subset of parvalbumin-positive interneurons in the dentate gyrus carries high densities of clustered dendritic spines, which predispose for plastic changes in gene expression and affect experience-dependent rewiring. Keywords: dendritic spines, interneurons, plasticity, parvalbumin, perineuronal net, pnn, dentate gyrus, enriched environment, re-wiring, clusterhttp://www.sciencedirect.com/science/article/pii/S2211124719307375 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Angelica Foggetti Gilda Baccini Philipp Arnold Thomas Schiffelholz Peer Wulff |
spellingShingle |
Angelica Foggetti Gilda Baccini Philipp Arnold Thomas Schiffelholz Peer Wulff Spiny and Non-spiny Parvalbumin-Positive Hippocampal Interneurons Show Different Plastic Properties Cell Reports |
author_facet |
Angelica Foggetti Gilda Baccini Philipp Arnold Thomas Schiffelholz Peer Wulff |
author_sort |
Angelica Foggetti |
title |
Spiny and Non-spiny Parvalbumin-Positive Hippocampal Interneurons Show Different Plastic Properties |
title_short |
Spiny and Non-spiny Parvalbumin-Positive Hippocampal Interneurons Show Different Plastic Properties |
title_full |
Spiny and Non-spiny Parvalbumin-Positive Hippocampal Interneurons Show Different Plastic Properties |
title_fullStr |
Spiny and Non-spiny Parvalbumin-Positive Hippocampal Interneurons Show Different Plastic Properties |
title_full_unstemmed |
Spiny and Non-spiny Parvalbumin-Positive Hippocampal Interneurons Show Different Plastic Properties |
title_sort |
spiny and non-spiny parvalbumin-positive hippocampal interneurons show different plastic properties |
publisher |
Elsevier |
series |
Cell Reports |
issn |
2211-1247 |
publishDate |
2019-06-01 |
description |
Summary: Dendritic spines control synaptic transmission and plasticity by augmenting post-synaptic potentials and providing biochemical compartmentalization. In principal cells, spines cover the dendritic tree at high densities, receive the overwhelming majority of excitatory inputs, and undergo experience-dependent structural re-organization. Although GABAergic interneurons have long been considered to be devoid of spines, a number of studies have reported the sparse existence of spines in interneurons. However, little is known about their organization or function at the cellular and network level. Here, we show that a subset of hippocampal parvalbumin-positive interneurons forms numerous dendritic spines with highly variable densities and input-selective organization. These spines form in areas with reduced perineuronal net sheathing, predispose for plastic changes in protein expression, and show input-specific re-organization after behavioral experience. : Dendritic spines on excitatory principal cells are critical sites of learning-induced plasticity. Foggetti et al. report that a subset of parvalbumin-positive interneurons in the dentate gyrus carries high densities of clustered dendritic spines, which predispose for plastic changes in gene expression and affect experience-dependent rewiring. Keywords: dendritic spines, interneurons, plasticity, parvalbumin, perineuronal net, pnn, dentate gyrus, enriched environment, re-wiring, cluster |
url |
http://www.sciencedirect.com/science/article/pii/S2211124719307375 |
work_keys_str_mv |
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