Design of a Dual-Technology Fusion Sensor Chip with a Ring Electrode for Biosensing Application
Quartz crystal microbalance (QCM) is still a new high-precision surface detection technique. However, the adsorption quality detected by the QCM currently contains a solvent-coupling quality and cannot separate the actual biomolecular mass. Local surface plasmon resonance (LSPR) can detect the mass...
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doaj-18e3870b8ec74e088be3e3d5812507242020-11-24T20:45:17ZengMDPI AGMicromachines2072-666X2019-02-0110215310.3390/mi10020153mi10020153Design of a Dual-Technology Fusion Sensor Chip with a Ring Electrode for Biosensing ApplicationCheng Ma0Jin Zhu1Xiaolong Li2Wei Zheng3College of Electronic and Information, Jiangsu University of Science and Technology, Zhenjiang 212003, ChinaCollege of Electronic and Information, Jiangsu University of Science and Technology, Zhenjiang 212003, ChinaCollege of Electronic and Information, Jiangsu University of Science and Technology, Zhenjiang 212003, ChinaCollege of Electronic and Information, Jiangsu University of Science and Technology, Zhenjiang 212003, ChinaQuartz crystal microbalance (QCM) is still a new high-precision surface detection technique. However, the adsorption quality detected by the QCM currently contains a solvent-coupling quality and cannot separate the actual biomolecular mass. Local surface plasmon resonance (LSPR) can detect the mass of biomolecules, but requires a certain contrast between the solvent of the surrounding medium and the refractive index of the adsorbed layer. The sensor chip, combining two compatible technologies, can realize the simultaneous detection of biomolecules and improve the refractive index sensitivity. The structure of our chip is to prepare the ring-shaped gold electrode on the upper surface of the quartz crystal, the circular gold electrode on the bottom surface, and the spherical gold nanoparticles arrays in the center region of the ring electrode to form a QCM/LSPR dual-technology chip. Through simulation, we finally get the size of the best energy trap by the two electrodes on the upper surface and the lower surface: the ring-top electrode with a thickness of 100 nm, an inner diameter of 4 mm, and an outer diameter of 8 mm; and the bottom electrode with a thickness of 100 nm and a radius of 6 mm. By comparing the refractive index sensitivity, we chose a spherical gold nanoparticle with a radius of 30 nm and a refractive sensitivity of 61.34 nm/RIU to design the LSPR sensor chip.https://www.mdpi.com/2072-666X/10/2/153gold nanoparticlesquartz crystal microbalance (QCM)local surface plasmon resonance (LSPR)gold electrodedual-technology chip |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cheng Ma Jin Zhu Xiaolong Li Wei Zheng |
spellingShingle |
Cheng Ma Jin Zhu Xiaolong Li Wei Zheng Design of a Dual-Technology Fusion Sensor Chip with a Ring Electrode for Biosensing Application Micromachines gold nanoparticles quartz crystal microbalance (QCM) local surface plasmon resonance (LSPR) gold electrode dual-technology chip |
author_facet |
Cheng Ma Jin Zhu Xiaolong Li Wei Zheng |
author_sort |
Cheng Ma |
title |
Design of a Dual-Technology Fusion Sensor Chip with a Ring Electrode for Biosensing Application |
title_short |
Design of a Dual-Technology Fusion Sensor Chip with a Ring Electrode for Biosensing Application |
title_full |
Design of a Dual-Technology Fusion Sensor Chip with a Ring Electrode for Biosensing Application |
title_fullStr |
Design of a Dual-Technology Fusion Sensor Chip with a Ring Electrode for Biosensing Application |
title_full_unstemmed |
Design of a Dual-Technology Fusion Sensor Chip with a Ring Electrode for Biosensing Application |
title_sort |
design of a dual-technology fusion sensor chip with a ring electrode for biosensing application |
publisher |
MDPI AG |
series |
Micromachines |
issn |
2072-666X |
publishDate |
2019-02-01 |
description |
Quartz crystal microbalance (QCM) is still a new high-precision surface detection technique. However, the adsorption quality detected by the QCM currently contains a solvent-coupling quality and cannot separate the actual biomolecular mass. Local surface plasmon resonance (LSPR) can detect the mass of biomolecules, but requires a certain contrast between the solvent of the surrounding medium and the refractive index of the adsorbed layer. The sensor chip, combining two compatible technologies, can realize the simultaneous detection of biomolecules and improve the refractive index sensitivity. The structure of our chip is to prepare the ring-shaped gold electrode on the upper surface of the quartz crystal, the circular gold electrode on the bottom surface, and the spherical gold nanoparticles arrays in the center region of the ring electrode to form a QCM/LSPR dual-technology chip. Through simulation, we finally get the size of the best energy trap by the two electrodes on the upper surface and the lower surface: the ring-top electrode with a thickness of 100 nm, an inner diameter of 4 mm, and an outer diameter of 8 mm; and the bottom electrode with a thickness of 100 nm and a radius of 6 mm. By comparing the refractive index sensitivity, we chose a spherical gold nanoparticle with a radius of 30 nm and a refractive sensitivity of 61.34 nm/RIU to design the LSPR sensor chip. |
topic |
gold nanoparticles quartz crystal microbalance (QCM) local surface plasmon resonance (LSPR) gold electrode dual-technology chip |
url |
https://www.mdpi.com/2072-666X/10/2/153 |
work_keys_str_mv |
AT chengma designofadualtechnologyfusionsensorchipwitharingelectrodeforbiosensingapplication AT jinzhu designofadualtechnologyfusionsensorchipwitharingelectrodeforbiosensingapplication AT xiaolongli designofadualtechnologyfusionsensorchipwitharingelectrodeforbiosensingapplication AT weizheng designofadualtechnologyfusionsensorchipwitharingelectrodeforbiosensingapplication |
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