Genetics in Atopic Dermatitis: Historical Perspective and Future Prospects
Atopic dermatitis (AD) is a common, complex trait, arising from the interplay of multiple genetic and environmental factors. This review provides an overview of developments in the field of AD genetics. AD shows high heritability; strategies to investigate genetic risk include linkage, candidate gen...
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Society for Publication of Acta Dermato-Venereologica
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doaj-18e78ef3670e45869781bf9d6c2879a82020-11-25T03:41:05ZengSociety for Publication of Acta Dermato-VenereologicaActa Dermato-Venereologica0001-55551651-20572020-06-0110012adv0016310.2340/00015555-35135768Genetics in Atopic Dermatitis: Historical Perspective and Future ProspectsSara J. Brown0Martina S. EliasMaria Bradley Skin Research Group, Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, DD1 9SY Dundee, United Kingdom. E-mail: s.j.brown@dundee.ac.uk. Atopic dermatitis (AD) is a common, complex trait, arising from the interplay of multiple genetic and environmental factors. This review provides an overview of developments in the field of AD genetics. AD shows high heritability; strategies to investigate genetic risk include linkage, candidate gene studies, genome-wide association and animal modelling. Loss-of-function mutations in FLG, encoding the skin barrier protein filaggrin, remain the strongest genetic risk factor identified for AD, but variants influencing skin and systemic immune function are also important. AD is at the forefront of genetic research, from large-scale population studies to in vitro models and detailed molecular analyses. An understanding of genetic risk factors has considerably improved knowledge of mechanisms leading to atopic skin inflammation. Together this work has identified avenues for therapeutic intervention, but further research is needed to fully realise the opportunities of personalised medicine for this complex disease, to optimise patient benefit. https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3513 atopic dermatitis eczema filaggrin genetic genome-wide risk phenotype transcriptome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sara J. Brown Martina S. Elias Maria Bradley |
spellingShingle |
Sara J. Brown Martina S. Elias Maria Bradley Genetics in Atopic Dermatitis: Historical Perspective and Future Prospects Acta Dermato-Venereologica atopic dermatitis eczema filaggrin genetic genome-wide risk phenotype transcriptome |
author_facet |
Sara J. Brown Martina S. Elias Maria Bradley |
author_sort |
Sara J. Brown |
title |
Genetics in Atopic Dermatitis: Historical Perspective and Future Prospects |
title_short |
Genetics in Atopic Dermatitis: Historical Perspective and Future Prospects |
title_full |
Genetics in Atopic Dermatitis: Historical Perspective and Future Prospects |
title_fullStr |
Genetics in Atopic Dermatitis: Historical Perspective and Future Prospects |
title_full_unstemmed |
Genetics in Atopic Dermatitis: Historical Perspective and Future Prospects |
title_sort |
genetics in atopic dermatitis: historical perspective and future prospects |
publisher |
Society for Publication of Acta Dermato-Venereologica |
series |
Acta Dermato-Venereologica |
issn |
0001-5555 1651-2057 |
publishDate |
2020-06-01 |
description |
Atopic dermatitis (AD) is a common, complex trait, arising from the interplay of multiple genetic and environmental factors. This review provides an overview of developments in the field of AD genetics. AD shows high heritability; strategies to investigate genetic risk include linkage, candidate gene studies, genome-wide association and animal modelling. Loss-of-function mutations in FLG, encoding the skin barrier protein filaggrin, remain the strongest genetic risk factor identified for AD, but variants influencing skin and systemic immune function are also important. AD is at the forefront of genetic research, from large-scale population studies to in vitro models and detailed molecular analyses. An understanding of genetic risk factors has considerably improved knowledge of mechanisms leading to atopic skin inflammation. Together this work has identified avenues for therapeutic intervention, but further research is needed to fully realise the opportunities of personalised medicine for this complex disease, to optimise patient benefit. |
topic |
atopic dermatitis eczema filaggrin genetic genome-wide risk phenotype transcriptome |
url |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3513
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work_keys_str_mv |
AT sarajbrown geneticsinatopicdermatitishistoricalperspectiveandfutureprospects AT martinaselias geneticsinatopicdermatitishistoricalperspectiveandfutureprospects AT mariabradley geneticsinatopicdermatitishistoricalperspectiveandfutureprospects |
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1724531922679365632 |