Local and Travel-Associated Transmission of Tuberculosis at Central Western Border of Brazil, 2014–2017
International migrants are at heightened risk for tuberculosis (TB) disease. Intensified incarceration at international borders may compound population-wide TB risk. However, few studies have investigated the contributions of migration, local transmission, or prisons in driving incident TB at inter...
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Centers for Disease Control and Prevention
2021-03-01
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Online Access: | https://wwwnc.cdc.gov/eid/article/27/3/20-3839_article |
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doaj-18e820767deb4364a55a4ade62875cf82021-02-22T23:22:54ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592021-03-0127390591410.3201/eid2703.203839Local and Travel-Associated Transmission of Tuberculosis at Central Western Border of Brazil, 2014–2017Katharine S. WalterMariana Bento TataraKesia Esther da SilvaFlora Martinez Figueira MoreiraPaulo Cesar Pereira dos SantosDândrea Driely de Melo FerrariEunice Atsuko CunhaJason R. AndrewsJulio Croda International migrants are at heightened risk for tuberculosis (TB) disease. Intensified incarceration at international borders may compound population-wide TB risk. However, few studies have investigated the contributions of migration, local transmission, or prisons in driving incident TB at international borders. We conducted prospective population-based genomic surveillance in 3 cities along Brazil’s central western border from 2014–2017. Although most isolates (89/132; 67%) fell within genomic transmission clusters, genetically unique isolates disproportionately occurred among participants with recent international travel (17/42; 40.5%), suggesting that both local transmission and migration contribute to incident TB. Isolates from 40 participants with and 76 without an incarceration history clustered together throughout a maximum-likelihood phylogeny, indicating the close interrelatedness of prison and community epidemics. Our findings highlight the need for ongoing surveillance to control continued introductions of TB and reduce the disproportionate burden of TB in prisons at Brazil’s international borders. https://wwwnc.cdc.gov/eid/article/27/3/20-3839_articletuberculosis and other mycobacteriatransmissiongenomic epidemiologymigrationbordersincarceration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Katharine S. Walter Mariana Bento Tatara Kesia Esther da Silva Flora Martinez Figueira Moreira Paulo Cesar Pereira dos Santos Dândrea Driely de Melo Ferrari Eunice Atsuko Cunha Jason R. Andrews Julio Croda |
spellingShingle |
Katharine S. Walter Mariana Bento Tatara Kesia Esther da Silva Flora Martinez Figueira Moreira Paulo Cesar Pereira dos Santos Dândrea Driely de Melo Ferrari Eunice Atsuko Cunha Jason R. Andrews Julio Croda Local and Travel-Associated Transmission of Tuberculosis at Central Western Border of Brazil, 2014–2017 Emerging Infectious Diseases tuberculosis and other mycobacteria transmission genomic epidemiology migration borders incarceration |
author_facet |
Katharine S. Walter Mariana Bento Tatara Kesia Esther da Silva Flora Martinez Figueira Moreira Paulo Cesar Pereira dos Santos Dândrea Driely de Melo Ferrari Eunice Atsuko Cunha Jason R. Andrews Julio Croda |
author_sort |
Katharine S. Walter |
title |
Local and Travel-Associated Transmission of Tuberculosis at Central Western Border of Brazil, 2014–2017 |
title_short |
Local and Travel-Associated Transmission of Tuberculosis at Central Western Border of Brazil, 2014–2017 |
title_full |
Local and Travel-Associated Transmission of Tuberculosis at Central Western Border of Brazil, 2014–2017 |
title_fullStr |
Local and Travel-Associated Transmission of Tuberculosis at Central Western Border of Brazil, 2014–2017 |
title_full_unstemmed |
Local and Travel-Associated Transmission of Tuberculosis at Central Western Border of Brazil, 2014–2017 |
title_sort |
local and travel-associated transmission of tuberculosis at central western border of brazil, 2014–2017 |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2021-03-01 |
description |
International migrants are at heightened risk for tuberculosis (TB) disease. Intensified incarceration at international borders may compound population-wide TB risk. However, few studies have investigated the contributions of migration, local transmission, or prisons in driving incident TB at international borders. We conducted prospective population-based genomic surveillance in 3 cities along Brazil’s central western border from 2014–2017. Although most isolates (89/132; 67%) fell within genomic transmission clusters, genetically unique isolates disproportionately occurred among participants with recent international travel (17/42; 40.5%), suggesting that both local transmission and migration contribute to incident TB. Isolates from 40 participants with and 76 without an incarceration history clustered together throughout a maximum-likelihood phylogeny, indicating the close interrelatedness of prison and community epidemics. Our findings highlight the need for ongoing surveillance to control continued introductions of TB and reduce the disproportionate burden of TB in prisons at Brazil’s international borders.
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topic |
tuberculosis and other mycobacteria transmission genomic epidemiology migration borders incarceration |
url |
https://wwwnc.cdc.gov/eid/article/27/3/20-3839_article |
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