Discoveries for Long Non-Coding RNA Dynamics in Traumatic Brain Injury
In recent years, our understanding of long non-coding RNAs (lncRNAs) has been challenged with advances in genome sequencing and the widespread use of high-throughput analysis for identifying novel lncRNAs. Since then, the characterization of lncRNAs has contributed to the establishment of their mole...
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doaj-18e9f3bf96914bde8e44f4d0de787d9f2020-12-11T00:03:42ZengMDPI AGBiology2079-77372020-12-01945845810.3390/biology9120458Discoveries for Long Non-Coding RNA Dynamics in Traumatic Brain InjuryKey-Hwan Lim0Sumin Yang1Sung-Hyun Kim2Sungkun Chun3Jae-Yeol Joo4Neurodegenerative Disease Research Group, Korea Brain Research Institute, Daegu 41062, KoreaNeurodegenerative Disease Research Group, Korea Brain Research Institute, Daegu 41062, KoreaNeurodegenerative Disease Research Group, Korea Brain Research Institute, Daegu 41062, KoreaDepartment of Physiology, Jeonbuk National University Medicine School, Jeonju 54907, KoreaNeurodegenerative Disease Research Group, Korea Brain Research Institute, Daegu 41062, KoreaIn recent years, our understanding of long non-coding RNAs (lncRNAs) has been challenged with advances in genome sequencing and the widespread use of high-throughput analysis for identifying novel lncRNAs. Since then, the characterization of lncRNAs has contributed to the establishment of their molecular roles and functions in transcriptional regulation. Although genetic studies have so far explored the sequence-based primary function of lncRNAs that guides the expression of target genes, recent insights have shed light on the potential of lncRNAs for widening the identification of biomarkers from non-degenerative to neurodegenerative diseases. Therefore, further advances in the genetic characteristics of lncRNAs are expected to lead to diagnostic accuracy during disease progression. In this review, we summarized the latest studies of lncRNAs in TBI as a non-degenerative disease and discussed their potential limitations for clinical treatment.https://www.mdpi.com/2079-7737/9/12/458biomarkerlong non-coding RNAnon-degenerative diseasetraumatic brain injury |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Key-Hwan Lim Sumin Yang Sung-Hyun Kim Sungkun Chun Jae-Yeol Joo |
spellingShingle |
Key-Hwan Lim Sumin Yang Sung-Hyun Kim Sungkun Chun Jae-Yeol Joo Discoveries for Long Non-Coding RNA Dynamics in Traumatic Brain Injury Biology biomarker long non-coding RNA non-degenerative disease traumatic brain injury |
author_facet |
Key-Hwan Lim Sumin Yang Sung-Hyun Kim Sungkun Chun Jae-Yeol Joo |
author_sort |
Key-Hwan Lim |
title |
Discoveries for Long Non-Coding RNA Dynamics in Traumatic Brain Injury |
title_short |
Discoveries for Long Non-Coding RNA Dynamics in Traumatic Brain Injury |
title_full |
Discoveries for Long Non-Coding RNA Dynamics in Traumatic Brain Injury |
title_fullStr |
Discoveries for Long Non-Coding RNA Dynamics in Traumatic Brain Injury |
title_full_unstemmed |
Discoveries for Long Non-Coding RNA Dynamics in Traumatic Brain Injury |
title_sort |
discoveries for long non-coding rna dynamics in traumatic brain injury |
publisher |
MDPI AG |
series |
Biology |
issn |
2079-7737 |
publishDate |
2020-12-01 |
description |
In recent years, our understanding of long non-coding RNAs (lncRNAs) has been challenged with advances in genome sequencing and the widespread use of high-throughput analysis for identifying novel lncRNAs. Since then, the characterization of lncRNAs has contributed to the establishment of their molecular roles and functions in transcriptional regulation. Although genetic studies have so far explored the sequence-based primary function of lncRNAs that guides the expression of target genes, recent insights have shed light on the potential of lncRNAs for widening the identification of biomarkers from non-degenerative to neurodegenerative diseases. Therefore, further advances in the genetic characteristics of lncRNAs are expected to lead to diagnostic accuracy during disease progression. In this review, we summarized the latest studies of lncRNAs in TBI as a non-degenerative disease and discussed their potential limitations for clinical treatment. |
topic |
biomarker long non-coding RNA non-degenerative disease traumatic brain injury |
url |
https://www.mdpi.com/2079-7737/9/12/458 |
work_keys_str_mv |
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