Immunosuppressive activity of tumor-infiltrating myeloid cells in patients with meningioma
Meningiomas WHO grade I and II are common intracranial tumors in adults that normally display a benign outcome, but are characterized by a great clinical heterogeneity and frequent recurrence of the disease. Although the presence of an immune cell infiltrate has been documented in these tumors, a cl...
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doaj-18ea33f0a89c4228a89c90c718e744462020-11-25T03:28:12ZengTaylor & Francis GroupOncoImmunology2162-402X2018-07-017710.1080/2162402X.2018.14409311440931Immunosuppressive activity of tumor-infiltrating myeloid cells in patients with meningiomaLaura Pinton0Samantha Solito1Elena Masetto2Marina Vettore3Stefania Canè4A. Della Puppa5Susanna Mandruzzato6Via GattamelataUniversity of PadovaVia GattamelataUniversity of PadovaVerona University HospitalAzienda Ospedaliera di PadovaVia GattamelataMeningiomas WHO grade I and II are common intracranial tumors in adults that normally display a benign outcome, but are characterized by a great clinical heterogeneity and frequent recurrence of the disease. Although the presence of an immune cell infiltrate has been documented in these tumors, a clear phenotypical and functional characterization of the immune web is missing. Here, we performed an extensive immunophenotyping of peripheral blood and fresh tumor tissue at surgery by multiparametric flow cytometry in 34 meningioma patients, along with immunosuppressive activity of sorted cells of myeloid origin. Four subsets of myeloid cells, phenotypically corresponding to myeloid-derived suppressor cells (MDSCs) are detectable in the blood and in the tumor tissue of patients and three of them are significantly expanded in the blood of patients, but show no evidence of suppressive activity. At the tumor site, a large leukocyte infiltrate is present, predominantly constituted by CD33+ myeloid cells, largely composed of macrophages endowed with suppressive activity and significantly expanded in grade II meningioma patients as compared to grade I.http://dx.doi.org/10.1080/2162402X.2018.1440931cnsinnate immunityimmune suppressionmeningiomamdscmyeloid cells |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Laura Pinton Samantha Solito Elena Masetto Marina Vettore Stefania Canè A. Della Puppa Susanna Mandruzzato |
spellingShingle |
Laura Pinton Samantha Solito Elena Masetto Marina Vettore Stefania Canè A. Della Puppa Susanna Mandruzzato Immunosuppressive activity of tumor-infiltrating myeloid cells in patients with meningioma OncoImmunology cns innate immunity immune suppression meningioma mdsc myeloid cells |
author_facet |
Laura Pinton Samantha Solito Elena Masetto Marina Vettore Stefania Canè A. Della Puppa Susanna Mandruzzato |
author_sort |
Laura Pinton |
title |
Immunosuppressive activity of tumor-infiltrating myeloid cells in patients with meningioma |
title_short |
Immunosuppressive activity of tumor-infiltrating myeloid cells in patients with meningioma |
title_full |
Immunosuppressive activity of tumor-infiltrating myeloid cells in patients with meningioma |
title_fullStr |
Immunosuppressive activity of tumor-infiltrating myeloid cells in patients with meningioma |
title_full_unstemmed |
Immunosuppressive activity of tumor-infiltrating myeloid cells in patients with meningioma |
title_sort |
immunosuppressive activity of tumor-infiltrating myeloid cells in patients with meningioma |
publisher |
Taylor & Francis Group |
series |
OncoImmunology |
issn |
2162-402X |
publishDate |
2018-07-01 |
description |
Meningiomas WHO grade I and II are common intracranial tumors in adults that normally display a benign outcome, but are characterized by a great clinical heterogeneity and frequent recurrence of the disease. Although the presence of an immune cell infiltrate has been documented in these tumors, a clear phenotypical and functional characterization of the immune web is missing. Here, we performed an extensive immunophenotyping of peripheral blood and fresh tumor tissue at surgery by multiparametric flow cytometry in 34 meningioma patients, along with immunosuppressive activity of sorted cells of myeloid origin. Four subsets of myeloid cells, phenotypically corresponding to myeloid-derived suppressor cells (MDSCs) are detectable in the blood and in the tumor tissue of patients and three of them are significantly expanded in the blood of patients, but show no evidence of suppressive activity. At the tumor site, a large leukocyte infiltrate is present, predominantly constituted by CD33+ myeloid cells, largely composed of macrophages endowed with suppressive activity and significantly expanded in grade II meningioma patients as compared to grade I. |
topic |
cns innate immunity immune suppression meningioma mdsc myeloid cells |
url |
http://dx.doi.org/10.1080/2162402X.2018.1440931 |
work_keys_str_mv |
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