The n-3 Polyunsaturated Fatty Acids Supplementation Improved the Cognitive Function in the Chinese Elderly with Mild Cognitive Impairment: A Double-Blind Randomized Controlled Trial
Objective: Intake of n-3 polyunsaturated fatty acids (n-3 PUFAs) may protect against mild cognitive impairment (MCI). However, there is still a lack of the n-3 PUFAs intervention in the elderly with MCI in China. The aim of the present study was to investigate the effect of n-3 PUFA supplementation...
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doaj-18ebdb8fc5b645e08fcf35dbc7f1e0c32020-11-25T00:38:34ZengMDPI AGNutrients2072-66432017-01-01915410.3390/nu9010054nu9010054The n-3 Polyunsaturated Fatty Acids Supplementation Improved the Cognitive Function in the Chinese Elderly with Mild Cognitive Impairment: A Double-Blind Randomized Controlled TrialYacong Bo0Xueyuan Zhang1Youli Wang2Jie You3Han Cui4Yiwei Zhu5Wei Pang6Wei Liu7Yugang Jiang8Quanjun Lu9Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaThe Center for Disease Control and Prevention of China Pingmei Shenma Group, Pingdingshan 467000, ChinaDepartment of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Nutrition, Tianjin Institute of Health and Environment Medicine, Tianjin 300050, ChinaDepartment of Nutrition, Tianjin Institute of Health and Environment Medicine, Tianjin 300050, ChinaDepartment of Nutrition, Tianjin Institute of Health and Environment Medicine, Tianjin 300050, ChinaDepartment of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaObjective: Intake of n-3 polyunsaturated fatty acids (n-3 PUFAs) may protect against mild cognitive impairment (MCI). However, there is still a lack of the n-3 PUFAs intervention in the elderly with MCI in China. The aim of the present study was to investigate the effect of n-3 PUFA supplementation on cognitive function in the Chinese elderly with MCI. Methods: Eighty six MCI individuals aged 60 years or older were randomly assigned to receive either n-3 PUFAs (480 mg DHA and 720 mg EPA per day, n = 44) or placebo (olive oil, n = 42) capsules. The changes of cognitive functions were assessed using Basic Cognitive Aptitude Tests (BCAT). Results: The mean age of participants was 71 years old, and 59% of the participants were men. n-3 PUFA supplementation was associated with improved total BCAT scores, perceptual speed, space imagery efficiency, and working memory (p < 0.01), but not with mental arithmetic efficiency or recognition memory (p > 0.05). Subgroup analysis by sex showed that n-3 PUFAs significantly improved perceptual speed (p = 0.001), space imagery efficiency (p = 0.013), working memory (p = 0.018), and total BCAT scores (p = 0.000) in males. However, in females, the significant beneficial effects can only be observed in perceptual speed (p = 0.027), space imagery efficiency (p = 0.006), and total BCAT scores (p = 0.015)—not working memory (p = 0.113). Conclusion: n-3 PUFAs can improve cognitive function in people with MCI. Further studies with different fish oil dosages, longer intervention periods, and larger sample sizes should be investigated before definite recommendations can be made.http://www.mdpi.com/2072-6643/9/1/54n-3 polyunsaturated fatty acidsmild cognitive impairmentelderlycognitionbasic cognitive aptitude tests |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yacong Bo Xueyuan Zhang Youli Wang Jie You Han Cui Yiwei Zhu Wei Pang Wei Liu Yugang Jiang Quanjun Lu |
spellingShingle |
Yacong Bo Xueyuan Zhang Youli Wang Jie You Han Cui Yiwei Zhu Wei Pang Wei Liu Yugang Jiang Quanjun Lu The n-3 Polyunsaturated Fatty Acids Supplementation Improved the Cognitive Function in the Chinese Elderly with Mild Cognitive Impairment: A Double-Blind Randomized Controlled Trial Nutrients n-3 polyunsaturated fatty acids mild cognitive impairment elderly cognition basic cognitive aptitude tests |
author_facet |
Yacong Bo Xueyuan Zhang Youli Wang Jie You Han Cui Yiwei Zhu Wei Pang Wei Liu Yugang Jiang Quanjun Lu |
author_sort |
Yacong Bo |
title |
The n-3 Polyunsaturated Fatty Acids Supplementation Improved the Cognitive Function in the Chinese Elderly with Mild Cognitive Impairment: A Double-Blind Randomized Controlled Trial |
title_short |
The n-3 Polyunsaturated Fatty Acids Supplementation Improved the Cognitive Function in the Chinese Elderly with Mild Cognitive Impairment: A Double-Blind Randomized Controlled Trial |
title_full |
The n-3 Polyunsaturated Fatty Acids Supplementation Improved the Cognitive Function in the Chinese Elderly with Mild Cognitive Impairment: A Double-Blind Randomized Controlled Trial |
title_fullStr |
The n-3 Polyunsaturated Fatty Acids Supplementation Improved the Cognitive Function in the Chinese Elderly with Mild Cognitive Impairment: A Double-Blind Randomized Controlled Trial |
title_full_unstemmed |
The n-3 Polyunsaturated Fatty Acids Supplementation Improved the Cognitive Function in the Chinese Elderly with Mild Cognitive Impairment: A Double-Blind Randomized Controlled Trial |
title_sort |
n-3 polyunsaturated fatty acids supplementation improved the cognitive function in the chinese elderly with mild cognitive impairment: a double-blind randomized controlled trial |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2017-01-01 |
description |
Objective: Intake of n-3 polyunsaturated fatty acids (n-3 PUFAs) may protect against mild cognitive impairment (MCI). However, there is still a lack of the n-3 PUFAs intervention in the elderly with MCI in China. The aim of the present study was to investigate the effect of n-3 PUFA supplementation on cognitive function in the Chinese elderly with MCI. Methods: Eighty six MCI individuals aged 60 years or older were randomly assigned to receive either n-3 PUFAs (480 mg DHA and 720 mg EPA per day, n = 44) or placebo (olive oil, n = 42) capsules. The changes of cognitive functions were assessed using Basic Cognitive Aptitude Tests (BCAT). Results: The mean age of participants was 71 years old, and 59% of the participants were men. n-3 PUFA supplementation was associated with improved total BCAT scores, perceptual speed, space imagery efficiency, and working memory (p < 0.01), but not with mental arithmetic efficiency or recognition memory (p > 0.05). Subgroup analysis by sex showed that n-3 PUFAs significantly improved perceptual speed (p = 0.001), space imagery efficiency (p = 0.013), working memory (p = 0.018), and total BCAT scores (p = 0.000) in males. However, in females, the significant beneficial effects can only be observed in perceptual speed (p = 0.027), space imagery efficiency (p = 0.006), and total BCAT scores (p = 0.015)—not working memory (p = 0.113). Conclusion: n-3 PUFAs can improve cognitive function in people with MCI. Further studies with different fish oil dosages, longer intervention periods, and larger sample sizes should be investigated before definite recommendations can be made. |
topic |
n-3 polyunsaturated fatty acids mild cognitive impairment elderly cognition basic cognitive aptitude tests |
url |
http://www.mdpi.com/2072-6643/9/1/54 |
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