Abnormal Striatal Development Underlies the Early Onset of Behavioral Deficits in Shank3B−/− Mice

Abnormal Striatal Development Underlies the Early Onset of Behavioral Deficits in Shank3B−/− Mice

Summary: The neural substrates and pathophysiological mechanisms underlying the onset of cognitive and motor deficits in autism spectrum disorders (ASDs) remain unclear. Mutations in ASD-associated SHANK3 in mice (Shank3B−/−) result in the accelerated maturation of corticostriatal circuits during th...

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Main Authors: Rui Tiago Peixoto, Lynne Chantranupong, Richard Hakim, James Levasseur, Wengang Wang, Tasha Merchant, Kelly Gorman, Bogdan Budnik, Bernardo Luis Sabatini
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471931321X

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