Hyperlipidemia in APOE2 transgenic mice is ameliorated by a truncated apoE variant lacking the C-terminal domain
Familial dysbetalipoproteinemia associated with the apolipoprotein E2 (APOE2) genotype is a recessive disorder with low penetrance. We have investigated whether additional expression of full-length APOE3, APOE4, or a truncated variant of APOE4 (APOE4-202) can reduce APOE2- associated hyperlipidemia....
Main Authors: | Gery Gerritsen, Kyriakos E. Kypreos, André van der Zee, Bas Teusink, Vassilis I. Zannis, Louis M. Havekes, Ko Willems van Dijk |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2003-02-01
|
Series: | Journal of Lipid Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520312281 |
Similar Items
-
ApoC-III deficiency prevents hyperlipidemia induced by apoE overexpression
by: Gery Gerritsen, et al.
Published: (2005-07-01) -
Apolipoprotein E2 (Arg136 → Cys) mutation in the receptor binding domain of apoE is not associated with dominant type III hyperlipoproteinemia1
by: Winfried März, et al.
Published: (1998-03-01) -
LDL receptor deficiency or apoE mutations prevent remnant clearance and induce hypertriglyceridemia in mices⃞
by: Kyriakos E. Kypreos, et al.
Published: (2006-03-01) -
Molecular etiology of a dominant form of type III hyperlipoproteinemia caused by R142C substitution in apoE4[S]
by: Alexander M. Vezeridis, et al.
Published: (2011-01-01) -
ApoE2-associated hypertriglyceridemia is ameliorated by increased levels of apoA-V but unaffected by apoC-III deficiency*
by: Gery Gerritsen, et al.
Published: (2008-05-01)