Impairments in path integration, rotational memory and balancing in patients with temporal lobe epilepsy
Objectives The vestibulo-medial temporal lobe (MTL) axis model proposes that the vestibular system and the MTL are tightly linked both structurally and functionally so that alterations of one structure should entail disturbances in the other. Accordingly, patients with temporal lobe epilepsy (TLE) w...
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doaj-18fd66159cbb418a95e7d40bf895eb532021-01-22T00:30:12ZengBMJ Publishing GroupBMJ Neurology Open2632-61402020-12-012210.1136/bmjno-2020-000077Impairments in path integration, rotational memory and balancing in patients with temporal lobe epilepsyMilos Dordevic0Julia Gruber1Friedhelm C Schmitt2Notger Mueller3Department of Neurology, Otto-von-Guericke-Universitat Magdeburg Medizinische Fakultät, Magdeburg, Sachsen-Anhalt, GermanyDZNE, Magdeburg, Sachsen-Anhalt, GermanyDepartment of Neurology, Otto-von-Guericke-Universitat Magdeburg Medizinische Fakultät, Magdeburg, Sachsen-Anhalt, GermanyDepartment of Neurology, Otto-von-Guericke-Universitat Magdeburg Medizinische Fakultät, Magdeburg, Sachsen-Anhalt, GermanyObjectives The vestibulo-medial temporal lobe (MTL) axis model proposes that the vestibular system and the MTL are tightly linked both structurally and functionally so that alterations of one structure should entail disturbances in the other. Accordingly, patients with temporal lobe epilepsy (TLE) with their functional and possible structural temporal lobe pathology should show deficits in vestibular-related behaviour. This study aimed at assessing behavioural deficits related to a suspected disturbance of the vestibulo-MTL axis in patients with TLE.Methods Twenty patients with TLE (46.7±15.1 years, seven females) and their age-matched and gender-matched controls (46.7±15.1, seven females) underwent three test batteries that challenged vestibular and MTL functions: balancing, path integration (triangle completion test) and rotational memory. In addition, participants underwent a structural MRI for grey matter analysis using voxel-based morphometry.Results Compared with controls, patients with TLE showed significantly inferior performance in all three behavioural tests, with large effect sizes. There were no significant grey matter differences between the two groups.Conclusion These results indicate a potential disturbance in the vestibulo-MTL axis in TLE; these are to be verified by future large-scale studies. In the current study, these behavioural deficits emerged without evidence of any brain volume differences between the patients and their controls as depicted by high-resolution MRI. This speaks for a dissociation between functional and structural alterations in TLE.https://neurologyopen.bmj.com/content/2/2/e000077.full |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Milos Dordevic Julia Gruber Friedhelm C Schmitt Notger Mueller |
spellingShingle |
Milos Dordevic Julia Gruber Friedhelm C Schmitt Notger Mueller Impairments in path integration, rotational memory and balancing in patients with temporal lobe epilepsy BMJ Neurology Open |
author_facet |
Milos Dordevic Julia Gruber Friedhelm C Schmitt Notger Mueller |
author_sort |
Milos Dordevic |
title |
Impairments in path integration, rotational memory and balancing in patients with temporal lobe epilepsy |
title_short |
Impairments in path integration, rotational memory and balancing in patients with temporal lobe epilepsy |
title_full |
Impairments in path integration, rotational memory and balancing in patients with temporal lobe epilepsy |
title_fullStr |
Impairments in path integration, rotational memory and balancing in patients with temporal lobe epilepsy |
title_full_unstemmed |
Impairments in path integration, rotational memory and balancing in patients with temporal lobe epilepsy |
title_sort |
impairments in path integration, rotational memory and balancing in patients with temporal lobe epilepsy |
publisher |
BMJ Publishing Group |
series |
BMJ Neurology Open |
issn |
2632-6140 |
publishDate |
2020-12-01 |
description |
Objectives The vestibulo-medial temporal lobe (MTL) axis model proposes that the vestibular system and the MTL are tightly linked both structurally and functionally so that alterations of one structure should entail disturbances in the other. Accordingly, patients with temporal lobe epilepsy (TLE) with their functional and possible structural temporal lobe pathology should show deficits in vestibular-related behaviour. This study aimed at assessing behavioural deficits related to a suspected disturbance of the vestibulo-MTL axis in patients with TLE.Methods Twenty patients with TLE (46.7±15.1 years, seven females) and their age-matched and gender-matched controls (46.7±15.1, seven females) underwent three test batteries that challenged vestibular and MTL functions: balancing, path integration (triangle completion test) and rotational memory. In addition, participants underwent a structural MRI for grey matter analysis using voxel-based morphometry.Results Compared with controls, patients with TLE showed significantly inferior performance in all three behavioural tests, with large effect sizes. There were no significant grey matter differences between the two groups.Conclusion These results indicate a potential disturbance in the vestibulo-MTL axis in TLE; these are to be verified by future large-scale studies. In the current study, these behavioural deficits emerged without evidence of any brain volume differences between the patients and their controls as depicted by high-resolution MRI. This speaks for a dissociation between functional and structural alterations in TLE. |
url |
https://neurologyopen.bmj.com/content/2/2/e000077.full |
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