Sterile immunity to malaria after DNA prime/adenovirus boost immunization is associated with effector memory CD8+T cells targeting AMA1 class I epitopes.

Sterile immunity to malaria after DNA prime/adenovirus boost immunization is associated with effector memory CD8+T cells targeting AMA1 class I epitopes.

Fifteen volunteers were immunized with three doses of plasmid DNA encoding P. falciparum circumsporozoite protein (CSP) and apical membrane antigen-1 (AMA1) and boosted with human adenovirus-5 (Ad) expressing the same antigens (DNA/Ad). Four volunteers (27%) demonstrated sterile immunity to controll...

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Bibliographic Details
Main Authors: Martha Sedegah, Michael R Hollingdale, Fouzia Farooq, Harini Ganeshan, Maria Belmonte, Yohan Kim, Bjoern Peters, Alessandro Sette, Jun Huang, Shannon McGrath, Esteban Abot, Keith Limbach, Meng Shi, Lorraine Soisson, Carter Diggs, Ilin Chuang, Cindy Tamminga, Judith E Epstein, Eileen Villasante, Thomas L Richie
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4161338?pdf=render

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