Histomorphological Spectrum of Nephrectomy Specimens- A Tertairy Care Centre Experience
Introduction: Nephrectomy is a common surgical procedure done for a variety of neoplastic and nonneoplastic diseases. This study has been taken up to analyze kidney diseases histopathologically and various lesions of the kidney and their subtypes and record the various lesions which have lead to...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Pvt. Ltd.
2016-04-01
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Series: | National Journal of Laboratory Medicine |
Subjects: | |
Online Access: | http://www.njlm.net/articles/PDF/2112/11-%2018261_F(P)_PF1(Vsu_Om)_PFA(Om)_PF2(OMVSU).pdf |
Summary: | Introduction: Nephrectomy is a common surgical
procedure done for a variety of neoplastic and nonneoplastic diseases. This study has been taken up to
analyze kidney diseases histopathologically and various
lesions of the kidney and their subtypes and record the
various lesions which have lead to partial nephrectomy,
total nephrectomy, unilateral and bilateral nephrectomies.
Aim: To study spectrum of diseases in nephrectomy
specimens, histological sub typing of neoplastic conditions
and evaluation of histopathological prognostic features like
capsular invasion, vascular invasion and nuclear grade.
Materials and Methods: This was an retrospective and
prospective analysis done over the period of 4 years
(2006-2009). A nephrectomy specimens received in the
Department of Pathology Dayanand Medical College and
Hospital, Ludhiana were analyzed with respect to gross
and microscopic features.
Results: Out of a total number of 155 cases, 82 were
neoplastic, 73 were non-neoplastic males were 98
and females 57 with a M:F ratio 1.7:1. Out of the 82
neoplastic cases, Renal cell carcinoma (Clear cell type)
was commonest (57 cases) followed by Transitional
cell carcinoma (07 cases), Papillary RCC (03 cases),
Oncocytoma (03 cases), Wilm’s tumour (02 cases), RCC
with sarcomatoid change (02 cases), RCC unclassifiable
(03 cases) and 01 case each of Chromophobe RCC,
Multicystic RCC, Collecting duct carcinoma and small
round cell tumour respectively. Of the 73 non-neoplastic
cases, chronic pyelonephritis with hydronephrosis
constituted 42 cases, emphysematous pyelonephritis (16
cases), xanthogranulomatous pyelonephritis (02 cases),
acute or chronic pyelonephritis (09 cases), polycystic
kidney (02 cases), cystic renal dysplasia and tuberculosis
(01 case each).
Conclusion: Radical nephrectomy is the common surgical
procedure done for both neoplastic disorders as well as non
neoplastic lesions. Detailed histopathological examination
is necessary for diagnosis and the prognostication of the
lesions. |
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ISSN: | 2277-8551 2455-6882 |