Epigenetic Regulation of Matrix Metalloproteinase-1 and -3 Expression in Mycobacterium tuberculosis Infection

Epigenetic Regulation of Matrix Metalloproteinase-1 and -3 Expression in Mycobacterium tuberculosis Infection

In pulmonary tuberculosis (TB), the inflammatory immune response against Mycobacterium tuberculosis (Mtb) is associated with tissue destruction and cavitation, which drives disease transmission, chronic lung disease, and mortality. Matrix metalloproteinase (MMP)-1 is a host enzyme critical for the d...

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Bibliographic Details
Main Authors: Rachel C. Moores, Sara Brilha, Frans Schutgens, Paul T. Elkington, Jon S. Friedland
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Immunology
Subjects:
Mycobacterium tuberculosis
matrix metalloproteinases
histone deacetylases
histone acetyltransferases
epigenetics
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00602/full

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