E46K Mutant α-Synuclein Is Degraded by Both Proteasome and Macroautophagy Pathway
Genetic studies have revealed that rare mutations and multiplications of the gene locus in α-synuclein (α-syn) are implicated in the pathogenesis of Parkinson’s disease (PD). However, the pathological effects of α-syn are still obscure. The neurotoxicity of &...
Main Authors: | Jia-qing Yan, Yu-he Yuan, Shi-feng Chu, Guo-hui Li, Nai-hong Chen |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2018-11-01
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Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/23/11/2839 |
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