Mitochondrial Impairment in Sarcopenia

Mitochondrial Impairment in Sarcopenia

Sarcopenia is defined by the age-related loss of skeletal muscle quality, which relies on mitochondrial homeostasis. During aging, several mitochondrial features such as bioenergetics, dynamics, biogenesis, and selective autophagy (mitophagy) are altered and impinge on protein homeostasis, resulting...

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Main Authors: Francesco Bellanti, Aurelio Lo Buglio, Gianluigi Vendemiale
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Biology
Subjects:
protein homeostasis
aging skeletal muscle
mitochondrial dysfunction
Online Access:https://www.mdpi.com/2079-7737/10/1/31
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spelling doaj-191a4ee4e57e40f7ac89eecbe02d30a52021-01-07T00:00:39ZengMDPI AGBiology2079-77372021-01-0110313110.3390/biology10010031Mitochondrial Impairment in SarcopeniaFrancesco Bellanti0Aurelio Lo Buglio1Gianluigi Vendemiale2Department of Medical and Surgical Sciences, University of Foggia, viale Pinto 1, 71122 Foggia, ItalyDepartment of Medical and Surgical Sciences, University of Foggia, viale Pinto 1, 71122 Foggia, ItalyDepartment of Medical and Surgical Sciences, University of Foggia, viale Pinto 1, 71122 Foggia, ItalySarcopenia is defined by the age-related loss of skeletal muscle quality, which relies on mitochondrial homeostasis. During aging, several mitochondrial features such as bioenergetics, dynamics, biogenesis, and selective autophagy (mitophagy) are altered and impinge on protein homeostasis, resulting in loss of muscle mass and function. Thus, mitochondrial dysfunction contributes significantly to the complex pathogenesis of sarcopenia, and mitochondria are indicated as potential targets to prevent and treat this age-related condition. After a concise presentation of the age-related modifications in skeletal muscle quality and mitochondrial homeostasis, the present review summarizes the most relevant findings related to mitochondrial alterations in sarcopenia.https://www.mdpi.com/2079-7737/10/1/31protein homeostasisaging skeletal musclemitochondrial dysfunction
collection DOAJ
language English
format Article
sources DOAJ
author Francesco Bellanti
Aurelio Lo Buglio
Gianluigi Vendemiale
spellingShingle Francesco Bellanti
Aurelio Lo Buglio
Gianluigi Vendemiale
Mitochondrial Impairment in Sarcopenia
Biology
protein homeostasis
aging skeletal muscle
mitochondrial dysfunction
author_facet Francesco Bellanti
Aurelio Lo Buglio
Gianluigi Vendemiale
author_sort Francesco Bellanti
title Mitochondrial Impairment in Sarcopenia
title_short Mitochondrial Impairment in Sarcopenia
title_full Mitochondrial Impairment in Sarcopenia
title_fullStr Mitochondrial Impairment in Sarcopenia
title_full_unstemmed Mitochondrial Impairment in Sarcopenia
title_sort mitochondrial impairment in sarcopenia
publisher MDPI AG
series Biology
issn 2079-7737
publishDate 2021-01-01
description Sarcopenia is defined by the age-related loss of skeletal muscle quality, which relies on mitochondrial homeostasis. During aging, several mitochondrial features such as bioenergetics, dynamics, biogenesis, and selective autophagy (mitophagy) are altered and impinge on protein homeostasis, resulting in loss of muscle mass and function. Thus, mitochondrial dysfunction contributes significantly to the complex pathogenesis of sarcopenia, and mitochondria are indicated as potential targets to prevent and treat this age-related condition. After a concise presentation of the age-related modifications in skeletal muscle quality and mitochondrial homeostasis, the present review summarizes the most relevant findings related to mitochondrial alterations in sarcopenia.
topic protein homeostasis
aging skeletal muscle
mitochondrial dysfunction
url https://www.mdpi.com/2079-7737/10/1/31
work_keys_str_mv AT francescobellanti mitochondrialimpairmentinsarcopenia
AT aureliolobuglio mitochondrialimpairmentinsarcopenia
AT gianluigivendemiale mitochondrialimpairmentinsarcopenia
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