Deep Cavitand Calixarene–Solubilized Fullerene as a Potential Photodynamic Agent
Fullerene has attracted much attention in biomedical research due to its unique physical and chemical properties. However, the hydrophobic nature of fullerene is limited to deploy in the body, given that the biofluids are mainly water. In this study, a water-soluble supramolecular nanoformulation ba...
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2021-06-01
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doaj-1920f4ea52ab4950a9a411f467c99aaf2021-07-19T13:16:47ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462021-06-01910.3389/fchem.2021.710808710808Deep Cavitand Calixarene–Solubilized Fullerene as a Potential Photodynamic AgentTian-Xing ZhangJuan-Juan LiHua-Bin LiDong-Sheng GuoFullerene has attracted much attention in biomedical research due to its unique physical and chemical properties. However, the hydrophobic nature of fullerene is limited to deploy in the body, given that the biofluids are mainly water. In this study, a water-soluble supramolecular nanoformulation based on a deep cavitand calixarene (SAC4A) and fullerene is developed to overcome the hydrophobicity of fullerene and is used as a potential photodynamic agent. SAC4A solubilizes fullerene very well with a simple grinding method. The significantly increased water solubility of fullerene enables efficient activation of reactive oxygen species. The host–guest strategy to solubilize fullerene can not only provide a new method to achieve water solubility but also expand the biomedical applications of fullerene.https://www.frontiersin.org/articles/10.3389/fchem.2021.710808/fullsupramolecular chemistryphotodynamic agentcalixarenefullerenesolubility |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tian-Xing Zhang Juan-Juan Li Hua-Bin Li Dong-Sheng Guo |
spellingShingle |
Tian-Xing Zhang Juan-Juan Li Hua-Bin Li Dong-Sheng Guo Deep Cavitand Calixarene–Solubilized Fullerene as a Potential Photodynamic Agent Frontiers in Chemistry supramolecular chemistry photodynamic agent calixarene fullerene solubility |
author_facet |
Tian-Xing Zhang Juan-Juan Li Hua-Bin Li Dong-Sheng Guo |
author_sort |
Tian-Xing Zhang |
title |
Deep Cavitand Calixarene–Solubilized Fullerene as a Potential Photodynamic Agent |
title_short |
Deep Cavitand Calixarene–Solubilized Fullerene as a Potential Photodynamic Agent |
title_full |
Deep Cavitand Calixarene–Solubilized Fullerene as a Potential Photodynamic Agent |
title_fullStr |
Deep Cavitand Calixarene–Solubilized Fullerene as a Potential Photodynamic Agent |
title_full_unstemmed |
Deep Cavitand Calixarene–Solubilized Fullerene as a Potential Photodynamic Agent |
title_sort |
deep cavitand calixarene–solubilized fullerene as a potential photodynamic agent |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Chemistry |
issn |
2296-2646 |
publishDate |
2021-06-01 |
description |
Fullerene has attracted much attention in biomedical research due to its unique physical and chemical properties. However, the hydrophobic nature of fullerene is limited to deploy in the body, given that the biofluids are mainly water. In this study, a water-soluble supramolecular nanoformulation based on a deep cavitand calixarene (SAC4A) and fullerene is developed to overcome the hydrophobicity of fullerene and is used as a potential photodynamic agent. SAC4A solubilizes fullerene very well with a simple grinding method. The significantly increased water solubility of fullerene enables efficient activation of reactive oxygen species. The host–guest strategy to solubilize fullerene can not only provide a new method to achieve water solubility but also expand the biomedical applications of fullerene. |
topic |
supramolecular chemistry photodynamic agent calixarene fullerene solubility |
url |
https://www.frontiersin.org/articles/10.3389/fchem.2021.710808/full |
work_keys_str_mv |
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