Microwave-Assisted Synthesis of Some 3,5-Arylated 2-Pyrazolines

Microwave-Assisted Synthesis of Some 3,5-Arylated 2-Pyrazolines

Condensation of 2-acetylnaphthalene with benzaldehydes under microwave irradiation affords chalcones which undergo facile and clean cyclizations with hydrazines RNHNH2 (R= H, Ph, Ac) to afford 3,5-arylated 2-pyrazolines in quantitative yields, also under microwave irradiation and in the presence of...

Full description

Bibliographic Details
Main Authors: Hassan Ghasemnejad, Davood Azarifar
Format: Article
Language:English
Published: MDPI AG 2003-07-01
Series:Molecules
Subjects:
Microwave irradiation
chalcones
3
5-arylated-2-pyrazolines
pyrazolines
heterocyclic synthesis
Online Access:http://www.mdpi.com/1420-3049/8/8/642/
Description
Summary:Condensation of 2-acetylnaphthalene with benzaldehydes under microwave irradiation affords chalcones which undergo facile and clean cyclizations with hydrazines RNHNH2 (R= H, Ph, Ac) to afford 3,5-arylated 2-pyrazolines in quantitative yields, also under microwave irradiation and in the presence of dry AcOH as cyclizing agent. The results obtained indicate that, unlike classical heating, microwave irradiation results in higher yields, shorter reaction times (2-12 min.) and cleaner reactions.
ISSN:1420-3049

Similar Items