Prevalence of Prediabetes and Diabetes Mellitus Type II in Bipolar Disorder
IntroductionBipolar disorder (BD) is characterized by recurrent episodes of depression and mania and affects up to 2% of the population worldwide. Patients suffering from bipolar disorder have a reduced life expectancy of up to 10 years. The increased mortality might be due to a higher rate of somat...
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Frontiers Media S.A.
2020-04-01
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Series: | Frontiers in Psychiatry |
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Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00314/full |
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doaj-193ab8b091f84032a870752a014f0962 |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sarah Kittel-Schneider Sarah Kittel-Schneider Daniel Bury Daniel Bury Karolina Leopold Karolina Leopold Sara Haack Michael Bauer Steffi Pfeiffer Cathrin Sauer Andrea Pfennig Henry Völzke Hans-Jörgen Grabe Andreas Reif |
spellingShingle |
Sarah Kittel-Schneider Sarah Kittel-Schneider Daniel Bury Daniel Bury Karolina Leopold Karolina Leopold Sara Haack Michael Bauer Steffi Pfeiffer Cathrin Sauer Andrea Pfennig Henry Völzke Hans-Jörgen Grabe Andreas Reif Prevalence of Prediabetes and Diabetes Mellitus Type II in Bipolar Disorder Frontiers in Psychiatry bipolar disorder diabetes mellitus prediabetes affective disorders metabolic syndrome glucose metabolism |
author_facet |
Sarah Kittel-Schneider Sarah Kittel-Schneider Daniel Bury Daniel Bury Karolina Leopold Karolina Leopold Sara Haack Michael Bauer Steffi Pfeiffer Cathrin Sauer Andrea Pfennig Henry Völzke Hans-Jörgen Grabe Andreas Reif |
author_sort |
Sarah Kittel-Schneider |
title |
Prevalence of Prediabetes and Diabetes Mellitus Type II in Bipolar Disorder |
title_short |
Prevalence of Prediabetes and Diabetes Mellitus Type II in Bipolar Disorder |
title_full |
Prevalence of Prediabetes and Diabetes Mellitus Type II in Bipolar Disorder |
title_fullStr |
Prevalence of Prediabetes and Diabetes Mellitus Type II in Bipolar Disorder |
title_full_unstemmed |
Prevalence of Prediabetes and Diabetes Mellitus Type II in Bipolar Disorder |
title_sort |
prevalence of prediabetes and diabetes mellitus type ii in bipolar disorder |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Psychiatry |
issn |
1664-0640 |
publishDate |
2020-04-01 |
description |
IntroductionBipolar disorder (BD) is characterized by recurrent episodes of depression and mania and affects up to 2% of the population worldwide. Patients suffering from bipolar disorder have a reduced life expectancy of up to 10 years. The increased mortality might be due to a higher rate of somatic diseases, especially cardiovascular diseases. There is however also evidence for an increased rate of diabetes mellitus in BD, but the reported prevalence rates vary by large.Material and Methods85 bipolar disorder patients were recruited in the framework of the BiDi study (Prevalence and clinical features of patients with Bipolar Disorder at High Risk for Type 2 Diabetes (T2D), at prediabetic state and with manifest T2D) in Dresden and Würzburg. T2D and prediabetes were diagnosed measuring HBA1c and an oral glucose tolerance test (oGTT), which at present is the gold standard in diagnosing T2D. The BD sample was compared to an age-, sex- and BMI-matched control population (n = 850) from the Study of Health in Pomerania cohort (SHIP Trend Cohort).ResultsPatients suffering from BD had a T2D prevalence of 7%, which was not significantly different from the control group (6%). Fasting glucose and impaired glucose tolerance were, contrary to our hypothesis, more often pathological in controls than in BD patients. Nondiabetic and diabetic bipolar patients significantly differed in age, BMI, number of depressive episodes, and disease duration.DiscussionWhen controlled for BMI, in our study there was no significantly increased rate of T2D in BD. We thus suggest that overweight and obesity might be mediating the association between BD and diabetes. Underlying causes could be shared risk genes, medication effects, and lifestyle factors associated with depressive episodes. As the latter two can be modified, attention should be paid to weight changes in BD by monitoring and taking adequate measures to prevent the alarming loss of life years in BD patients. |
topic |
bipolar disorder diabetes mellitus prediabetes affective disorders metabolic syndrome glucose metabolism |
url |
https://www.frontiersin.org/article/10.3389/fpsyt.2020.00314/full |
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doaj-193ab8b091f84032a870752a014f09622020-11-25T03:31:50ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-04-011110.3389/fpsyt.2020.00314530237Prevalence of Prediabetes and Diabetes Mellitus Type II in Bipolar DisorderSarah Kittel-Schneider0Sarah Kittel-Schneider1Daniel Bury2Daniel Bury3Karolina Leopold4Karolina Leopold5Sara Haack6Michael Bauer7Steffi Pfeiffer8Cathrin Sauer9Andrea Pfennig10Henry Völzke11Hans-Jörgen Grabe12Andreas Reif13Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt, GermanyDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Julius-Maximilians-University of Würzburg, Würzburg, GermanyDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Julius-Maximilians-University of Würzburg, Würzburg, GermanyDepartment of Psychiatry and Psychotherapy Munich East, kbo-Isar-Amper-Klinikum, Haar, GermanyDepartment of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Medical Faculty, Technische Universität Dresden, Dresden, GermanyDepartment of Psychiatry, Psychotherapy and Psychosomatics, Vivantes Hospital am Urban and Vivantes Hospital im Friedrichshain, Charite Universitätsmedizin, Berlin, GermanyDepartment of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Medical Faculty, Technische Universität Dresden, Dresden, GermanyDepartment of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Medical Faculty, Technische Universität Dresden, Dresden, GermanyDepartment of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Medical Faculty, Technische Universität Dresden, Dresden, GermanyDepartment of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Medical Faculty, Technische Universität Dresden, Dresden, GermanyDepartment of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Medical Faculty, Technische Universität Dresden, Dresden, GermanyInstitute for Community Medicine, University Medicine Greifswald, Greifswald, GermanyDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, GermanyDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt, GermanyIntroductionBipolar disorder (BD) is characterized by recurrent episodes of depression and mania and affects up to 2% of the population worldwide. Patients suffering from bipolar disorder have a reduced life expectancy of up to 10 years. The increased mortality might be due to a higher rate of somatic diseases, especially cardiovascular diseases. There is however also evidence for an increased rate of diabetes mellitus in BD, but the reported prevalence rates vary by large.Material and Methods85 bipolar disorder patients were recruited in the framework of the BiDi study (Prevalence and clinical features of patients with Bipolar Disorder at High Risk for Type 2 Diabetes (T2D), at prediabetic state and with manifest T2D) in Dresden and Würzburg. T2D and prediabetes were diagnosed measuring HBA1c and an oral glucose tolerance test (oGTT), which at present is the gold standard in diagnosing T2D. The BD sample was compared to an age-, sex- and BMI-matched control population (n = 850) from the Study of Health in Pomerania cohort (SHIP Trend Cohort).ResultsPatients suffering from BD had a T2D prevalence of 7%, which was not significantly different from the control group (6%). Fasting glucose and impaired glucose tolerance were, contrary to our hypothesis, more often pathological in controls than in BD patients. Nondiabetic and diabetic bipolar patients significantly differed in age, BMI, number of depressive episodes, and disease duration.DiscussionWhen controlled for BMI, in our study there was no significantly increased rate of T2D in BD. We thus suggest that overweight and obesity might be mediating the association between BD and diabetes. Underlying causes could be shared risk genes, medication effects, and lifestyle factors associated with depressive episodes. As the latter two can be modified, attention should be paid to weight changes in BD by monitoring and taking adequate measures to prevent the alarming loss of life years in BD patients.https://www.frontiersin.org/article/10.3389/fpsyt.2020.00314/fullbipolar disorderdiabetes mellitusprediabetesaffective disordersmetabolic syndromeglucose metabolism |