Genetic testing in myelodysplastic syndromes contribution in diagnosis, prognostic and clinical management
Myelodysplastic syndromes (MDS) represent a group of clonal hematological malignancies characterized by ineffective hematopoiesis. Other hematological disorders associating dysplastic features are grouped under the myelodysplastic/ myeloproliferative neoplasms (MDS/MPN) category. The great diversity...
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"Alexandru Ioan Cuza" University of Iași
2010-06-01
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Series: | Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara |
Online Access: | http://www.gbm.bio.uaic.ro/index.php/gbm/article/view/746 |
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doaj-193ff4b4404f4b6d820ccc98ba61ed522020-11-25T00:03:45Zeng"Alexandru Ioan Cuza" University of IașiAnalele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara 1582-35712248-32762010-06-01112-3739Genetic testing in myelodysplastic syndromes contribution in diagnosis, prognostic and clinical managementAurora ArghirSorina Mihaela ChirieacNicoleta BerbecOana CiocanAndreea Cristina Tutulan-CunitaAgripina LungeanuMyelodysplastic syndromes (MDS) represent a group of clonal hematological malignancies characterized by ineffective hematopoiesis. Other hematological disorders associating dysplastic features are grouped under the myelodysplastic/ myeloproliferative neoplasms (MDS/MPN) category. The great diversity of the acquired chromosomal abnormalities described in MDS highlights the molecular heterogeneity of these diseases. We report on 12 MDS and 3 MDS/MPN patients investigated by cytogenetic and molecular techniques (FISH). The most frequent chromosomal anomalies were 5q deletion and trisomy 8. Other trisomies, deletions and new translocations were also detected. MDS and MDS/MPN stand as challenging entities in hemato-oncology due to their heterogeneity. Thus, genetic testing provides important means for diagnosis confirmation and offers further insight into the prognosis and management of these patients.http://www.gbm.bio.uaic.ro/index.php/gbm/article/view/746 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aurora Arghir Sorina Mihaela Chirieac Nicoleta Berbec Oana Ciocan Andreea Cristina Tutulan-Cunita Agripina Lungeanu |
spellingShingle |
Aurora Arghir Sorina Mihaela Chirieac Nicoleta Berbec Oana Ciocan Andreea Cristina Tutulan-Cunita Agripina Lungeanu Genetic testing in myelodysplastic syndromes contribution in diagnosis, prognostic and clinical management Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara |
author_facet |
Aurora Arghir Sorina Mihaela Chirieac Nicoleta Berbec Oana Ciocan Andreea Cristina Tutulan-Cunita Agripina Lungeanu |
author_sort |
Aurora Arghir |
title |
Genetic testing in myelodysplastic syndromes contribution in diagnosis, prognostic and clinical management |
title_short |
Genetic testing in myelodysplastic syndromes contribution in diagnosis, prognostic and clinical management |
title_full |
Genetic testing in myelodysplastic syndromes contribution in diagnosis, prognostic and clinical management |
title_fullStr |
Genetic testing in myelodysplastic syndromes contribution in diagnosis, prognostic and clinical management |
title_full_unstemmed |
Genetic testing in myelodysplastic syndromes contribution in diagnosis, prognostic and clinical management |
title_sort |
genetic testing in myelodysplastic syndromes contribution in diagnosis, prognostic and clinical management |
publisher |
"Alexandru Ioan Cuza" University of Iași |
series |
Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara |
issn |
1582-3571 2248-3276 |
publishDate |
2010-06-01 |
description |
Myelodysplastic syndromes (MDS) represent a group of clonal hematological malignancies characterized by
ineffective hematopoiesis. Other hematological disorders associating dysplastic features are grouped under the
myelodysplastic/ myeloproliferative neoplasms (MDS/MPN) category. The great diversity of the acquired chromosomal
abnormalities described in MDS highlights the molecular heterogeneity of these diseases. We report on 12 MDS and 3
MDS/MPN patients investigated by cytogenetic and molecular techniques (FISH). The most frequent chromosomal
anomalies were 5q deletion and trisomy 8. Other trisomies, deletions and new translocations were also detected. MDS
and MDS/MPN stand as challenging entities in hemato-oncology due to their heterogeneity. Thus, genetic testing
provides important means for diagnosis confirmation and offers further insight into the prognosis and management of
these patients. |
url |
http://www.gbm.bio.uaic.ro/index.php/gbm/article/view/746 |
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