Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability

Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability

Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences on chromatin remodeling and gene expression profiles. We provide here a review on the recent knowledge accrued on t...

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Bibliographic Details
Main Authors: Giorgio Milazzo, Daniele Mercatelli, Giulia Di Muzio, Luca Triboli, Piergiuseppe De Rosa, Giovanni Perini, Federico M. Giorgi
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Genes
Subjects:
histone deacetylases
HDAC
chromatin
epigenetics
epigenomics
HDAC inhibitors
Online Access:https://www.mdpi.com/2073-4425/11/5/556

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