Greener and efficient one-pot synthesis of novel multi-substituted 3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole derivatives by using recyclable catalyst under microwave irradiation

Greener and efficient one-pot synthesis of novel multi-substituted 3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole derivatives by using recyclable catalyst under microwave irradiation

The novel class of multi-substituted indolylimidazole derivatives series substituted 3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole and substituted 5-bromo-3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole was synthesized utilising a green and efficient one-pot four components condensation of indole...

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Main Authors: Nirwan, Narendra, Pareek, Chandresh
Format: Article
Language:English
Published: Growing Science 2021-01-01
Series:Current Chemistry Letters
Online Access:http://www.growingscience.com/ccl/Vol10/ccl_2021_8.pdf
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spelling doaj-19543a3dedaf4d6495f8f34a067d689e2021-03-31T10:18:44ZengGrowing ScienceCurrent Chemistry Letters1927-72961927-730X2021-01-0126127010.5267/j.ccl.2021.2.002Greener and efficient one-pot synthesis of novel multi-substituted 3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole derivatives by using recyclable catalyst under microwave irradiationNirwan, NarendraPareek, Chandresh The novel class of multi-substituted indolylimidazole derivatives series substituted 3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole and substituted 5-bromo-3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole was synthesized utilising a green and efficient one-pot four components condensation of indole-3-carbaldehyde, benzil, ammonium acetate and various amines under microwave irradiation using Amberlyst A-15 as a recyclable catalyst. The catalyst Amberlyst A-15 has recovered from the reaction mixture and reused repeatedly for the next reaction. The key advantage of this process involves eco-friendly, very short reaction time, cost-effectiveness with the reusability of catalyst, easy workup, and purification of the product with excellent yields. FTIR, 1HNMR and Mass spectrometric studies analyzed and established the structures of all newly synthesized compounds.http://www.growingscience.com/ccl/Vol10/ccl_2021_8.pdf
collection DOAJ
language English
format Article
sources DOAJ
author Nirwan, Narendra
Pareek, Chandresh
spellingShingle Nirwan, Narendra
Pareek, Chandresh
Greener and efficient one-pot synthesis of novel multi-substituted 3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole derivatives by using recyclable catalyst under microwave irradiation
Current Chemistry Letters
author_facet Nirwan, Narendra
Pareek, Chandresh
author_sort Nirwan, Narendra
title Greener and efficient one-pot synthesis of novel multi-substituted 3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole derivatives by using recyclable catalyst under microwave irradiation
title_short Greener and efficient one-pot synthesis of novel multi-substituted 3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole derivatives by using recyclable catalyst under microwave irradiation
title_full Greener and efficient one-pot synthesis of novel multi-substituted 3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole derivatives by using recyclable catalyst under microwave irradiation
title_fullStr Greener and efficient one-pot synthesis of novel multi-substituted 3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole derivatives by using recyclable catalyst under microwave irradiation
title_full_unstemmed Greener and efficient one-pot synthesis of novel multi-substituted 3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole derivatives by using recyclable catalyst under microwave irradiation
title_sort greener and efficient one-pot synthesis of novel multi-substituted 3-(4,5-diphenyl-1h-imidazol-2-yl)-1h-indole derivatives by using recyclable catalyst under microwave irradiation
publisher Growing Science
series Current Chemistry Letters
issn 1927-7296
1927-730X
publishDate 2021-01-01
description The novel class of multi-substituted indolylimidazole derivatives series substituted 3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole and substituted 5-bromo-3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole was synthesized utilising a green and efficient one-pot four components condensation of indole-3-carbaldehyde, benzil, ammonium acetate and various amines under microwave irradiation using Amberlyst A-15 as a recyclable catalyst. The catalyst Amberlyst A-15 has recovered from the reaction mixture and reused repeatedly for the next reaction. The key advantage of this process involves eco-friendly, very short reaction time, cost-effectiveness with the reusability of catalyst, easy workup, and purification of the product with excellent yields. FTIR, 1HNMR and Mass spectrometric studies analyzed and established the structures of all newly synthesized compounds.
url http://www.growingscience.com/ccl/Vol10/ccl_2021_8.pdf
work_keys_str_mv AT nirwannarendra greenerandefficientonepotsynthesisofnovelmultisubstituted345diphenyl1himidazol2yl1hindolederivativesbyusingrecyclablecatalystundermicrowaveirradiation
AT pareekchandresh greenerandefficientonepotsynthesisofnovelmultisubstituted345diphenyl1himidazol2yl1hindolederivativesbyusingrecyclablecatalystundermicrowaveirradiation
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