Seroprevalence of anti-hepatitis E virus (HEV) in a Korean population: comparison of two commercial anti-HEV assays
<p>Abstract</p> <p>Background</p> <p>Hepatitis E virus (HEV) has emerged as an important cause of epidemic and sporadic acute viral hepatitis worldwide. This study investigated the seroprevalence of anti-HEV in a Korean population and compared the performance of two com...
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doaj-1954540e82fa4dc48be7060725495f2e2020-11-25T03:11:50ZengBMCBMC Infectious Diseases1471-23342012-06-0112114210.1186/1471-2334-12-142Seroprevalence of anti-hepatitis E virus (HEV) in a Korean population: comparison of two commercial anti-HEV assaysPark HyunJeong Sook-HyangKim Jin-WookWoo Byung-HyunLee DongKim HyunAhn Soyeon<p>Abstract</p> <p>Background</p> <p>Hepatitis E virus (HEV) has emerged as an important cause of epidemic and sporadic acute viral hepatitis worldwide. This study investigated the seroprevalence of anti-HEV in a Korean population and compared the performance of two commercially available anti-HEV assays.</p> <p>Methods</p> <p>A total 147 health-check examinees were randomly sampled as matched to the age- and sex- adjusted standard population based on the Korean National Census of 2007. Serum immunoglobulin G anti-HEV was determined by using the Genelabs assay (Genelabs, Singapore) and the Wantai assay (Wantai, Beijing, China).</p> <p>Results</p> <p>The overall anti-HEV seroprevalence was 23.1% (95% CI, 16.1-30.1%) using the Wantai assay and 14.3% (95% CI, 8.3-20.3%) using the Genelabs assay. Only 12 samples (8.1%) were positive for anti-HEV as measured by both assays; agreement between the two assays was poor (kappa value of 0.315). The anti-HEV seroprevalence increased with age from 2% and 3% in the people younger than 20-years-of-age to 34.6% and 42.3% in those over 59-years-of-age by the Genelabs and Wantai assay, respectively.</p> <p>Conclusions</p> <p>The HEV seroprevalence in Korean population is about 20% overall, with seroprevalence increasing in this population with increasing age. There was poor concordance in the results of the Genelabs and Wantai assays, which warrants further study concerning a reliable diagnostic test for the diagnosis of hepatitis E.</p> http://www.biomedcentral.com/1471-2334/12/142Hepatitis E virusSeroprevalenceAnti-HEV assayKorea |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Park Hyun Jeong Sook-Hyang Kim Jin-Wook Woo Byung-Hyun Lee Dong Kim Hyun Ahn Soyeon |
spellingShingle |
Park Hyun Jeong Sook-Hyang Kim Jin-Wook Woo Byung-Hyun Lee Dong Kim Hyun Ahn Soyeon Seroprevalence of anti-hepatitis E virus (HEV) in a Korean population: comparison of two commercial anti-HEV assays BMC Infectious Diseases Hepatitis E virus Seroprevalence Anti-HEV assay Korea |
author_facet |
Park Hyun Jeong Sook-Hyang Kim Jin-Wook Woo Byung-Hyun Lee Dong Kim Hyun Ahn Soyeon |
author_sort |
Park Hyun |
title |
Seroprevalence of anti-hepatitis E virus (HEV) in a Korean population: comparison of two commercial anti-HEV assays |
title_short |
Seroprevalence of anti-hepatitis E virus (HEV) in a Korean population: comparison of two commercial anti-HEV assays |
title_full |
Seroprevalence of anti-hepatitis E virus (HEV) in a Korean population: comparison of two commercial anti-HEV assays |
title_fullStr |
Seroprevalence of anti-hepatitis E virus (HEV) in a Korean population: comparison of two commercial anti-HEV assays |
title_full_unstemmed |
Seroprevalence of anti-hepatitis E virus (HEV) in a Korean population: comparison of two commercial anti-HEV assays |
title_sort |
seroprevalence of anti-hepatitis e virus (hev) in a korean population: comparison of two commercial anti-hev assays |
publisher |
BMC |
series |
BMC Infectious Diseases |
issn |
1471-2334 |
publishDate |
2012-06-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Hepatitis E virus (HEV) has emerged as an important cause of epidemic and sporadic acute viral hepatitis worldwide. This study investigated the seroprevalence of anti-HEV in a Korean population and compared the performance of two commercially available anti-HEV assays.</p> <p>Methods</p> <p>A total 147 health-check examinees were randomly sampled as matched to the age- and sex- adjusted standard population based on the Korean National Census of 2007. Serum immunoglobulin G anti-HEV was determined by using the Genelabs assay (Genelabs, Singapore) and the Wantai assay (Wantai, Beijing, China).</p> <p>Results</p> <p>The overall anti-HEV seroprevalence was 23.1% (95% CI, 16.1-30.1%) using the Wantai assay and 14.3% (95% CI, 8.3-20.3%) using the Genelabs assay. Only 12 samples (8.1%) were positive for anti-HEV as measured by both assays; agreement between the two assays was poor (kappa value of 0.315). The anti-HEV seroprevalence increased with age from 2% and 3% in the people younger than 20-years-of-age to 34.6% and 42.3% in those over 59-years-of-age by the Genelabs and Wantai assay, respectively.</p> <p>Conclusions</p> <p>The HEV seroprevalence in Korean population is about 20% overall, with seroprevalence increasing in this population with increasing age. There was poor concordance in the results of the Genelabs and Wantai assays, which warrants further study concerning a reliable diagnostic test for the diagnosis of hepatitis E.</p> |
topic |
Hepatitis E virus Seroprevalence Anti-HEV assay Korea |
url |
http://www.biomedcentral.com/1471-2334/12/142 |
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