Betaine attenuates LPS-induced downregulation of Occludin and Claudin-1 and restores intestinal barrier function

Betaine attenuates LPS-induced downregulation of Occludin and Claudin-1 and restores intestinal barrier function

Abstract Background The intestinal epithelial barrier, which works as the first line of defense between the luminal environment and the host, once destroyed, it will cause serious inflammation or other intestinal diseases. Tight junctions (TJs) play a vital role to maintain the integrity of the epit...

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Bibliographic Details
Main Authors: Jingtao Wu, Caimei He, Jie Bu, Yue Luo, Shuyuan Yang, Chengyan Ye, Silei Yu, Binsheng He, Yulong Yin, Xiaoping Yang
Format: Article
Language:English
Published: BMC 2020-03-01
Series:BMC Veterinary Research
Subjects:
Betaine
Tight junctions
Transepithelial electrical resistance
Intestinal porcine epithelial cells
Online Access:http://link.springer.com/article/10.1186/s12917-020-02298-3

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