New Progress in Angiogenesis Therapy of Cardiovascular Disease by Ultrasound Targeted Microbubble Destruction
Angiogenesis plays a vital part in the pathogenesis and treatment of cardiovascular disease and has become one of the hotspots that are being discussed in the past decades. At present, the promising angiogenesis therapies are gene therapy and stem cell therapy. Besides, a series of studies have sh...
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Online Access: | http://dx.doi.org/10.1155/2014/872984 |
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doaj-198467c71a564c5790fba4d2e2ade6882020-11-25T00:00:26ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/872984872984New Progress in Angiogenesis Therapy of Cardiovascular Disease by Ultrasound Targeted Microbubble DestructionYang-Ying Liao0Zhi-Yi Chen1Yi-Xiang Wang2Yan Lin3Feng Yang4Qiu-Lan Zhou5Laboratory of Ultrasound Molecular Imaging, Department of Ultrasound Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, ChinaLaboratory of Ultrasound Molecular Imaging, Department of Ultrasound Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, ChinaDepartment of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong KongLaboratory of Ultrasound Molecular Imaging, Department of Ultrasound Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, ChinaLaboratory of Ultrasound Molecular Imaging, Department of Ultrasound Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, ChinaLaboratory of Ultrasound Molecular Imaging, Department of Ultrasound Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, ChinaAngiogenesis plays a vital part in the pathogenesis and treatment of cardiovascular disease and has become one of the hotspots that are being discussed in the past decades. At present, the promising angiogenesis therapies are gene therapy and stem cell therapy. Besides, a series of studies have shown that the ultrasound targeted microbubble destruction (UTMD) was a novel gene delivery system, due to its advantages of noninvasiveness, low immunogenicity and toxicity, repeatability and temporal and spatial target specificity; UTMD has also been used for angiogenesis therapy of cardiovascular disease. In this review, we mainly discuss the combination of UTMD and gene therapy or stem cell therapy which is applied in angiogenesis therapy in recent researches, and outline the future challenges and good prospects of these approaches.http://dx.doi.org/10.1155/2014/872984 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yang-Ying Liao Zhi-Yi Chen Yi-Xiang Wang Yan Lin Feng Yang Qiu-Lan Zhou |
spellingShingle |
Yang-Ying Liao Zhi-Yi Chen Yi-Xiang Wang Yan Lin Feng Yang Qiu-Lan Zhou New Progress in Angiogenesis Therapy of Cardiovascular Disease by Ultrasound Targeted Microbubble Destruction BioMed Research International |
author_facet |
Yang-Ying Liao Zhi-Yi Chen Yi-Xiang Wang Yan Lin Feng Yang Qiu-Lan Zhou |
author_sort |
Yang-Ying Liao |
title |
New Progress in Angiogenesis Therapy of Cardiovascular Disease by Ultrasound Targeted Microbubble Destruction |
title_short |
New Progress in Angiogenesis Therapy of Cardiovascular Disease by Ultrasound Targeted Microbubble Destruction |
title_full |
New Progress in Angiogenesis Therapy of Cardiovascular Disease by Ultrasound Targeted Microbubble Destruction |
title_fullStr |
New Progress in Angiogenesis Therapy of Cardiovascular Disease by Ultrasound Targeted Microbubble Destruction |
title_full_unstemmed |
New Progress in Angiogenesis Therapy of Cardiovascular Disease by Ultrasound Targeted Microbubble Destruction |
title_sort |
new progress in angiogenesis therapy of cardiovascular disease by ultrasound targeted microbubble destruction |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2014-01-01 |
description |
Angiogenesis plays a vital part in the pathogenesis and treatment of cardiovascular disease and has become one of the hotspots that are being discussed in the past decades. At present, the promising angiogenesis therapies are gene therapy and stem cell therapy. Besides, a series of studies have shown that the ultrasound targeted microbubble destruction (UTMD) was a novel gene delivery system, due to its advantages of noninvasiveness, low immunogenicity and toxicity, repeatability and temporal and spatial target specificity; UTMD has also been used for angiogenesis therapy of cardiovascular disease. In this review, we mainly discuss the combination of UTMD and gene therapy or stem cell therapy which is applied in angiogenesis therapy in recent researches, and outline the future challenges and good prospects of these approaches. |
url |
http://dx.doi.org/10.1155/2014/872984 |
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